Cerebral small vessel endothelial structural changes predate hypertension in stroke-prone spontaneously hypertensive rats: a blinded, controlled immunohistochemical study of 5- to 21-week-old rats

E L Bailey; J M Wardlaw; D Graham; A F Dominiczak; C L M Sudlow; C Smith

doi:10.1111/j.1365-2990.2011.01170.x

Cerebral small vessel endothelial structural changes predate hypertension in stroke-prone spontaneously hypertensive rats: a blinded, controlled immunohistochemical study of 5- to 21-week-old rats

E L Bailey, J M Wardlaw, D Graham, A F Dominiczak, C L M Sudlow, C Smith

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Abstract

The spontaneously hypertensive stroke-prone rat (SHRSP) is a potential animal model of human lacunar stroke, but there is little information on SHRSP small vessel pathology, especially in young rats. We investigated the structural changes that occur in cortical and subcortical vessels and adjacent tissue in SHRSP before, during and after the onset of hypertension.

Original language	English
Pages (from-to)	711-26
Number of pages	16
Journal	Neuropathology and Applied Neurobiology
Volume	37
Issue number	7
DOIs	https://doi.org/10.1111/j.1365-2990.2011.01170.x
Publication status	Published - 11 Mar 2011

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Bailey, E. L., Wardlaw, J. M., Graham, D., Dominiczak, A. F., Sudlow, C. L. M., & Smith, C. (2011). Cerebral small vessel endothelial structural changes predate hypertension in stroke-prone spontaneously hypertensive rats: a blinded, controlled immunohistochemical study of 5- to 21-week-old rats. Neuropathology and Applied Neurobiology, 37(7), 711-26. https://doi.org/10.1111/j.1365-2990.2011.01170.x

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title = "Cerebral small vessel endothelial structural changes predate hypertension in stroke-prone spontaneously hypertensive rats: a blinded, controlled immunohistochemical study of 5- to 21-week-old rats",

abstract = "The spontaneously hypertensive stroke-prone rat (SHRSP) is a potential animal model of human lacunar stroke, but there is little information on SHRSP small vessel pathology, especially in young rats. We investigated the structural changes that occur in cortical and subcortical vessels and adjacent tissue in SHRSP before, during and after the onset of hypertension.",

author = "Bailey, \{E L\} and Wardlaw, \{J M\} and D Graham and Dominiczak, \{A F\} and Sudlow, \{C L M\} and C Smith",

note = "{\textcopyright} 2011 The Authors. Neuropathology and Applied Neurobiology {\textcopyright} 2011 British Neuropathological Society.",

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doi = "10.1111/j.1365-2990.2011.01170.x",

language = "English",

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Bailey, EL, Wardlaw, JM, Graham, D, Dominiczak, AF, Sudlow, CLM & Smith, C 2011, 'Cerebral small vessel endothelial structural changes predate hypertension in stroke-prone spontaneously hypertensive rats: a blinded, controlled immunohistochemical study of 5- to 21-week-old rats', Neuropathology and Applied Neurobiology, vol. 37, no. 7, pp. 711-26. https://doi.org/10.1111/j.1365-2990.2011.01170.x

Cerebral small vessel endothelial structural changes predate hypertension in stroke-prone spontaneously hypertensive rats: a blinded, controlled immunohistochemical study of 5- to 21-week-old rats. / Bailey, E L; Wardlaw, J M; Graham, D et al.
In: Neuropathology and Applied Neurobiology, Vol. 37, No. 7, 11.03.2011, p. 711-26.

Research output: Contribution to journal › Article › peer-review

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AB - The spontaneously hypertensive stroke-prone rat (SHRSP) is a potential animal model of human lacunar stroke, but there is little information on SHRSP small vessel pathology, especially in young rats. We investigated the structural changes that occur in cortical and subcortical vessels and adjacent tissue in SHRSP before, during and after the onset of hypertension.

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Bailey EL, Wardlaw JM, Graham D, Dominiczak AF, Sudlow CLM , Smith C. Cerebral small vessel endothelial structural changes predate hypertension in stroke-prone spontaneously hypertensive rats: a blinded, controlled immunohistochemical study of 5- to 21-week-old rats. Neuropathology and Applied Neurobiology. 2011 Mar 11;37(7):711-26. doi: 10.1111/j.1365-2990.2011.01170.x

Cerebral small vessel endothelial structural changes predate hypertension in stroke-prone spontaneously hypertensive rats: a blinded, controlled immunohistochemical study of 5- to 21-week-old rats

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