Cerebrospinal fluid real-time quaking-induced conversion is a robust and reliable test for sporadic creutzfeldt–jakob disease: An international study

Lynne I. McGuire, Anna Poleggi, Ilaria Poggiolini , Silvia Suardi, Katarina Grznarova , Song Shi , Bart de Vil , Shannon Sarros , Katsuya Satoh, Keding Cheng , Maria Cramm , Graham Fairfoul , Matthias Schmitz, Inga Zerr, Patrick Cras , Michele Equestre, Fabrizio Tagliavini, Ryuichiro Atarashi , David Knox , Steven CollinsStéphane Haik, Piero Parchi, Maurizio Pocchiari, Alison Green

Research output: Contribution to journalArticlepeer-review

Abstract

Real‐time quaking‐induced conversion (RT‐QuIC) has been proposed as a sensitive diagnostic test for sporadic Creutzfeldt–Jakob disease; however, before this assay can be introduced into clinical practice, its reliability and reproducibility need to be demonstrated. Two international ring trials were undertaken in which a set of 25 cerebrospinal fluid samples were analyzed by a total of 11 different centers using a range of recombinant prion protein substrates and instrumentation. The results show almost complete concordance between the centers and demonstrate that RT‐QuIC is a suitably reliable and robust technique for clinical practice.
Original languageEnglish
Pages (from-to)160-165
Number of pages6
JournalAnnals of Neurology
Volume80
Issue number1
Early online date30 Apr 2016
DOIs
Publication statusPublished - 31 Jul 2016

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