Cerebrovascular Reactivity in Patients With Small Vessel Disease: A Cross-Sectional Study

Emilie Sleight; Michael s. Stringer; Una Clancy; Carmen Arteaga Reyes; Daniela Jaime garcia; Will Hewins; Angela C. C. Jochems; Olivia k.l. Hamilton; Cameron Manning; Alasdair g. Morgan; Rachel Locherty; Yajun Cheng; Xiaodi Liu; Junfang Zhang; Iona Hamilton; Charlotte Jardine; Rosalind Brown; Eleni Sakka; Agniete Kampaite; Stewart Wiseman; Maria c. Valdés-Hernández; Francesca m. Chappell; Fergus n. Doubal; Ian Marshall; Michael j. Thrippleton; Joanna m. Wardlaw

doi:10.1161/STROKEAHA.123.042656

Cerebrovascular Reactivity in Patients With Small Vessel Disease: A Cross-Sectional Study

Emilie Sleight, Michael s. Stringer, Una Clancy, Carmen Arteaga Reyes, Daniela Jaime garcia, Will Hewins, Angela C. C. Jochems, Olivia k.l. Hamilton, Cameron Manning, Alasdair g. Morgan, Rachel Locherty, Yajun Cheng, Xiaodi Liu, Junfang Zhang, Iona Hamilton, Charlotte Jardine, Rosalind Brown, Eleni Sakka, Agniete Kampaite, Stewart WisemanMaria c. Valdés-Hernández, Francesca m. Chappell, Fergus n. Doubal, Ian Marshall, Michael j. Thrippleton, Joanna m. Wardlaw

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Stroke
DOIs	https://doi.org/10.1161/STROKEAHA.123.042656
Publication status	Published - 10 Oct 2023

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10.1161/STROKEAHA.123.042656

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Sleight, E., Stringer, M. S., Clancy, U., Arteaga Reyes, C., Jaime garcia, D., Hewins, W., Jochems, A. C. C., Hamilton, O. K. L., Manning, C., Morgan, A. G., Locherty, R., Cheng, Y., Liu, X., Zhang, J., Hamilton, I., Jardine, C., Brown, R., Sakka, E., Kampaite, A., ... Wardlaw, J. M. (2023). Cerebrovascular Reactivity in Patients With Small Vessel Disease: A Cross-Sectional Study. Stroke. https://doi.org/10.1161/STROKEAHA.123.042656

@article{e59601a72b5a4639a605bea8a7f3f32c,

title = "Cerebrovascular Reactivity in Patients With Small Vessel Disease: A Cross-Sectional Study",

author = "Emilie Sleight and Stringer, {Michael s.} and Una Clancy and {Arteaga Reyes}, Carmen and {Jaime garcia}, Daniela and Will Hewins and Jochems, {Angela C. C.} and Hamilton, {Olivia k.l.} and Cameron Manning and Morgan, {Alasdair g.} and Rachel Locherty and Yajun Cheng and Xiaodi Liu and Junfang Zhang and Iona Hamilton and Charlotte Jardine and Rosalind Brown and Eleni Sakka and Agniete Kampaite and Stewart Wiseman and Vald{\'e}s-Hern{\'a}ndez, {Maria c.} and Chappell, {Francesca m.} and Doubal, {Fergus n.} and Ian Marshall and Thrippleton, {Michael j.} and Wardlaw, {Joanna m.}",

note = "Funding Information: Drs Morgan and Stringer receive funding from Siemens Healthineers. The other authors report no conflicts. Funding Information: Dr Sleight is funded by the Medical Research Council (MRC) National Productivity Fund (MR/R502327) and, with A.C.C. Jochems, acknowledges support from the University of Edinburgh College of Medicine and Veterinary Medicine (CMVM). Drs Sleight, Stringer, Arteaga, and Wardlaw are funded by the UK Dementia Research Institute (UKDRI), which receives funding from UKDRI, Ltd, funded by the MRC, Alzheimer{\textquoteright}s Society, and Alzheimer{\textquoteright}s Research UK. This work received funding from the UKDRI, European Union Horizon 2020 (PHC-03-15, project No. 666881 SVDs@Target), Fondation Leducq Transatlantic Network of Excellence for the Study of Perivascular Spaces in Small Vessel Disease (reference No. 16CVD 05). Furthermore, W. Hewins, Dr Wiseman, and R. Locherty acknowledge funding from Stroke Association (SVD-SOS [Small Vessel Disease - Spotlight On Symptoms], SA PG 19\100068; Stroke Association Postdoctoral Fellowship 18\100026); A.C.C. Jochems from Alzheimer{\textquoteright}s Society (ref 486 [AS-CP-18b-001]); Dr Vald{\'e}s-Hern{\'a}ndez, from the Row Fogo Center for Research Into Ageing and the Brain (AD.ROW4.35. BRO-D.FID3668413); Dr Thrippleton from the Scottish Chief Scientist Office through the NHS Lothian Research and Development Office; Dr Clancy from the Chief Scientist Office (CAF/18/08), Princess Margaret Stroke Association Research Development Fellowship and SCREDS (Scottish Clinical Research Excellence Development Scheme) Lectureship Scheme; Dr Arteaga from the Mexican National Council of Science and Technology, Anne Rowling Regenerative Neurology Clinic, and Row Fogo Center for Research Into Small Vessel Diseases; Dr Doubal from The Stroke Association-Garfield Weston Foundation (The Stroke Association Lectureship 2015/04), NHS Research Scotland, and Agnes Parry Endowment at the University of Edinburgh; D.J. Garcia from the Wellcome Trust; Dr Cheng from the China Scholarship Council; and Dr Liu from University of Hong Kong Foundation Postgraduate Fellowship. At the time of contribution, Dr Hamilton was funded by the University of Edinburgh CMVM as part of the Wellcome Trust 4-year PhD in Translational Neuroscience. The 3T research scanner is funded by the Wellcome Trust (104916/Z/14/Z), Dunhill Trust (R380R/1114), Edinburgh and Lothians Health Foundation (2012/17), Muir Maxwell Research Fund, and University of Edinburgh. For the purpose of open access, the author has applied a CC-BY public copyright license to any author accepted manuscript version arising from this submission. Publisher Copyright: {\textcopyright} 2023 The Authors. Stroke is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc.",

year = "2023",

month = oct,

day = "10",

doi = "10.1161/STROKEAHA.123.042656",

language = "English",

journal = "Stroke",

issn = "0039-2499",

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}

Sleight, E, Stringer, MS , Clancy, U , Arteaga Reyes, C, Jaime garcia, D, Hewins, W, Jochems, ACC, Hamilton, OKL, Manning, C, Morgan, AG, Locherty, R, Cheng, Y, Liu, X, Zhang, J, Hamilton, I, Jardine, C , Brown, R , Sakka, E , Kampaite, A , Wiseman, S , Valdés-Hernández, MC , Chappell, FM , Doubal, FN , Marshall, I , Thrippleton, MJ & Wardlaw, JM 2023, 'Cerebrovascular Reactivity in Patients With Small Vessel Disease: A Cross-Sectional Study', Stroke. https://doi.org/10.1161/STROKEAHA.123.042656

TY - JOUR

T1 - Cerebrovascular Reactivity in Patients With Small Vessel Disease: A Cross-Sectional Study

AU - Sleight, Emilie

AU - Stringer, Michael s.

AU - Clancy, Una

AU - Arteaga Reyes, Carmen

AU - Jaime garcia, Daniela

AU - Hewins, Will

AU - Jochems, Angela C. C.

AU - Hamilton, Olivia k.l.

AU - Manning, Cameron

AU - Morgan, Alasdair g.

AU - Locherty, Rachel

AU - Cheng, Yajun

AU - Liu, Xiaodi

AU - Zhang, Junfang

AU - Hamilton, Iona

AU - Jardine, Charlotte

AU - Brown, Rosalind

AU - Sakka, Eleni

AU - Kampaite, Agniete

AU - Wiseman, Stewart

AU - Valdés-Hernández, Maria c.

AU - Chappell, Francesca m.

AU - Doubal, Fergus n.

AU - Marshall, Ian

AU - Thrippleton, Michael j.

AU - Wardlaw, Joanna m.

N1 - Funding Information: Drs Morgan and Stringer receive funding from Siemens Healthineers. The other authors report no conflicts. Funding Information: Dr Sleight is funded by the Medical Research Council (MRC) National Productivity Fund (MR/R502327) and, with A.C.C. Jochems, acknowledges support from the University of Edinburgh College of Medicine and Veterinary Medicine (CMVM). Drs Sleight, Stringer, Arteaga, and Wardlaw are funded by the UK Dementia Research Institute (UKDRI), which receives funding from UKDRI, Ltd, funded by the MRC, Alzheimer’s Society, and Alzheimer’s Research UK. This work received funding from the UKDRI, European Union Horizon 2020 (PHC-03-15, project No. 666881 SVDs@Target), Fondation Leducq Transatlantic Network of Excellence for the Study of Perivascular Spaces in Small Vessel Disease (reference No. 16CVD 05). Furthermore, W. Hewins, Dr Wiseman, and R. Locherty acknowledge funding from Stroke Association (SVD-SOS [Small Vessel Disease - Spotlight On Symptoms], SA PG 19\100068; Stroke Association Postdoctoral Fellowship 18\100026); A.C.C. Jochems from Alzheimer’s Society (ref 486 [AS-CP-18b-001]); Dr Valdés-Hernández, from the Row Fogo Center for Research Into Ageing and the Brain (AD.ROW4.35. BRO-D.FID3668413); Dr Thrippleton from the Scottish Chief Scientist Office through the NHS Lothian Research and Development Office; Dr Clancy from the Chief Scientist Office (CAF/18/08), Princess Margaret Stroke Association Research Development Fellowship and SCREDS (Scottish Clinical Research Excellence Development Scheme) Lectureship Scheme; Dr Arteaga from the Mexican National Council of Science and Technology, Anne Rowling Regenerative Neurology Clinic, and Row Fogo Center for Research Into Small Vessel Diseases; Dr Doubal from The Stroke Association-Garfield Weston Foundation (The Stroke Association Lectureship 2015/04), NHS Research Scotland, and Agnes Parry Endowment at the University of Edinburgh; D.J. Garcia from the Wellcome Trust; Dr Cheng from the China Scholarship Council; and Dr Liu from University of Hong Kong Foundation Postgraduate Fellowship. At the time of contribution, Dr Hamilton was funded by the University of Edinburgh CMVM as part of the Wellcome Trust 4-year PhD in Translational Neuroscience. The 3T research scanner is funded by the Wellcome Trust (104916/Z/14/Z), Dunhill Trust (R380R/1114), Edinburgh and Lothians Health Foundation (2012/17), Muir Maxwell Research Fund, and University of Edinburgh. For the purpose of open access, the author has applied a CC-BY public copyright license to any author accepted manuscript version arising from this submission. Publisher Copyright: © 2023 The Authors. Stroke is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc.

PY - 2023/10/10

Y1 - 2023/10/10

U2 - 10.1161/STROKEAHA.123.042656

DO - 10.1161/STROKEAHA.123.042656

M3 - Article

SN - 0039-2499

JO - Stroke

JF - Stroke

ER -