Abstract
Background: Data on recruitment of Mild Cognitive Impairment (MCI) samples are seldom reported and this issue can be an important source of research waste.
Aims: To describe the recruitment challenges and reasons for non-eligibility faced during a bi-centres clinical study assessing the predictive value of a neuropsychological battery of the progression to dementia.
Methods: Potential MCI participants were identified from databases of the two memory clinics based in Milan (Italy) and invited to the screening assessment.
Results: About 50% of the cases initially identified were ineligible according to inclusion/exclusion criteria and the two sites took 22 months to recruit the planned 150 people. The main reason for non-eligibility were the MMSE score (41%), age (14%), presence of cerebrovascular disorders (9%), perceptual deficits (6%), neurological (6%) or psychiatric (4%) comorbidities and low education (5%).
Discussion/ Conclusion. Awareness of the reasons for exclusion and of the time needed to recruit the planned sample would provide hints for the planning of future studies on MCI.
Aims: To describe the recruitment challenges and reasons for non-eligibility faced during a bi-centres clinical study assessing the predictive value of a neuropsychological battery of the progression to dementia.
Methods: Potential MCI participants were identified from databases of the two memory clinics based in Milan (Italy) and invited to the screening assessment.
Results: About 50% of the cases initially identified were ineligible according to inclusion/exclusion criteria and the two sites took 22 months to recruit the planned 150 people. The main reason for non-eligibility were the MMSE score (41%), age (14%), presence of cerebrovascular disorders (9%), perceptual deficits (6%), neurological (6%) or psychiatric (4%) comorbidities and low education (5%).
Discussion/ Conclusion. Awareness of the reasons for exclusion and of the time needed to recruit the planned sample would provide hints for the planning of future studies on MCI.
| Original language | English |
|---|---|
| Pages (from-to) | 2007-2010 |
| Journal | Aging Clinical and Experimental Research |
| Volume | 33 |
| Issue number | 7 |
| Early online date | 14 Oct 2020 |
| DOIs | |
| Publication status | Published - Jul 2021 |
Keywords / Materials (for Non-textual outputs)
- MCI
- recruitment
- eligibility
- clinical research
- neuropsychology