Challenging the obesity paradox: Extreme obesity and COPD mortality in the SUMMIT Trial

Emily Brigham, Julie A Anderson, Robert D Brook, Peter Calverley, Bartolome R. Celli, Nicholas J Cowans, Courtney Crim, James Diserens, Fernando J. Martinez, Meredith McCormack, David E Newby, Julie C. Yates, Jørgen Vestbo, Tianshi Wu, Robert A. Wise

Research output: Contribution to journalArticlepeer-review

Abstract

Populations with COPD demonstrate higher survival in overweight and obese compared with normal weight; the “obesity paradox.” Relationships in less severe COPD are unclear, as is the impact of cardiovascular risk, and few studies include individuals at extremes of obesity. We examined the relationship between body mass index (BMI, defined as underweight: <20kg/m2, normal: 20-25kg/m2, overweight: 25- <30kg/m2, obese class I: 30-<35kg/m2, class II: 35-<40kg/m2, class III: >40kg/m2), morbidity, and mortality in the SUMMIT trial population (n=16,485), characterized by moderate COPD and heightened cardiovascular risk with a substantial proportion with class III obesity. The association between BMI category and time to event was modeled via proportional hazards (reference normal weight) adjusted for demographics and cardiorespiratory disease. Consistent with the paradox, underweight individuals demonstrated higher mortality (HR 1.31 (95%CI 1.04-1.64)), with lower mortality among overweight (HR 0.62 (95%CI 0.52-0.73)) and obese class I (HR 0.75 (95%CI 0.62-0.90)). However, mortality increased in obese class III (HR 1.36 (95%CI 1.00-1.86)). Death was primarily attributable to cardiovascular causes. Within a large, multinational cohort with moderate COPD and increased cardiovascular risk, the phenomenon of reduced mortality with obesity did not persist at BMI>40kg/m2, suggesting that obesity may not remain protective at the extremes in this population.
Original languageEnglish
JournalERJ Open Research
Early online date17 Jun 2021
DOIs
Publication statusE-pub ahead of print - 17 Jun 2021

Keywords

  • COPD
  • obesity
  • mortality

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