Changes in brain activity and connectivity as memories age

Francesco Gobbo, Rufus Mitchell-Heggs, Dorothy Tse

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The role of the hippocampus during memory consolidation is not fully understood, with human and animal experiments producing conflicting conclusions. In particular, human lesion studies tend to indicate that the hippocampus gradually becomes independent from memory over years, whilst animal studies suggest that this can happen over days. Tallman et al. (this issue) used fMRI to investigate activity and functional connectivity in the brain at four different time points following memory encoding. Their findings include a decrease in functional connectivity between the hippocampus and parahippocampal cortex with memory age, which supports the system consolidation theory, but also argues against the reduced involvement of the hippocampus over time. This study sheds new light on the neurobiology of memory.

Original languageEnglish
Pages (from-to)141-143
Number of pages3
JournalCognitive Neuroscience
Volume13
Issue number3-4
Early online date13 Jun 2022
DOIs
Publication statusPublished - Jul 2022

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Humans
  • Memory Consolidation
  • Hippocampus/diagnostic imaging
  • Brain Mapping
  • Magnetic Resonance Imaging
  • Brain/diagnostic imaging

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