Changes in Brain Tissue Oxygenation and Metabolism During Rewarming After Neonatal Encephalopathy are Related to Electrical Abnormality

Subhabrata Mitra, Gemma Bale, Isabel de Roever, Judith Meek, Nicola J Robertson, Ilias Tachtsidis

Research output: Contribution to journalArticlepeer-review

Abstract

Hypoxic ischemic encephalopathy (HIE) leads to significant mortality and morbidity, and therapeutic hypothermia (TH) has become a standard of care following HIE. After TH, the body temperature is brought back to 37 °C. Early electroencephalography (EEG) is a reliable outcome biomarker following HIE. We hypothesized that changes in cerebral oxidative metabolism, measured as Δ[oxCCO], in relation to changes in brain tissue oxygenation (measured as Δ[HbD]) during rewarming will correlate with injury severity as evidenced on amplitude integrated EEG/EEG at initial presentation. Broadband near-infrared spectroscopy (NIRS) and systemic data were collected during rewarming from 14 infants following HIE over a mean period of 12.5 h. All infants were monitored with video EEG telemetry using a standard neonatal montage. aEEG and EEG background was classified into mild, moderate and severely abnormal groups based on the background pattern. Two infants had mild, 6 infants had moderate and another 6 infants had severe abnormality at presentation. The relationship between [oxCCO] and [HbD] was evaluated between two groups of infants with abnormal electrical activity (mild vs moderate to severe). A significant difference was noted between the groups in the relationship between [oxCCO] and [HbD] (as r2) (p = 0.02). This result indicates that the mitochondrial injury and deranged oxidative metabolism persists in the moderate to severely abnormal group during rewarming.

Original languageEnglish
Pages (from-to)25-31
Number of pages7
JournalAdvances in Experimental Medicine and Biology
Volume1232
DOIs
Publication statusPublished - 2020

Keywords

  • Biomarkers/analysis
  • Brain/metabolism
  • Electroencephalography
  • Humans
  • Hypothermia, Induced
  • Hypoxia-Ischemia, Brain/diagnosis
  • Infant
  • Infant, Newborn
  • Rewarming

Fingerprint Dive into the research topics of 'Changes in Brain Tissue Oxygenation and Metabolism During Rewarming After Neonatal Encephalopathy are Related to Electrical Abnormality'. Together they form a unique fingerprint.

Cite this