Changes in duodenal CD163-positive cells in dogs with chronic enteropathy after successful treatment

Julien Rs Dandrieux, Lina Maria Martinez Lopez, Andrew Stent, Albert Jergens, Karin Allenspach, Cameron J Nowell, Simon M Firestone, Wayne Kimpton, Caroline S Mansfield

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Chronic enteropathy (CE) in dogs is characterized retrospectively per treatment response as food-responsive enteropathy (FRE), antibiotic-responsive enteropathy (ARE), and immunosuppressant-responsive enteropathy (IRE) - the latter most resembling inflammatory bowel disease in people. The aim of this study was to characterize duodenal macrophages (Mϕ) in CE using immunohistochemistry; with calprotectin (CAL) as a marker of early differentiated Mϕ and CD163 expression as a marker for resident Mϕ in the duodenum before and after treatment. Prior to treatment, dogs with FRE and IRE had a lower CD163+/CAL+ ratio than control dogs (CTRL) in crypts; this increased significantly and normalized compared with CTRL after treatment. Conversely, the CD163+/CAL+ ratio in dogs with ARE was comparable to that in healthy dogs before and after treatment. In summary, these results suggest that Mϕ play a role in the pathogenesis of CE in FRE and IRE, with a decrease in resident Mϕ and an increase in early differentiated Mϕ, but not in ARE dogs. Mϕ normalize after successful treatment.

Original languageEnglish
Pages (from-to)400-410
Number of pages11
JournalInnate Immunity
Issue number7
Early online date17 Sept 2018
Publication statusE-pub ahead of print - 17 Sept 2018

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Antigens, CD/metabolism
  • Antigens, Differentiation, Myelomonocytic/metabolism
  • Biomarkers/metabolism
  • Cell Differentiation
  • Disease Models, Animal
  • Dogs
  • Duodenum/immunology
  • Female
  • Humans
  • Immunohistochemistry
  • Inflammatory Bowel Diseases/drug therapy
  • Leukocyte L1 Antigen Complex/metabolism
  • Macrophages/immunology
  • Male
  • Receptors, Cell Surface/metabolism
  • Retrospective Studies


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