Changes in vaginal morphology, steroid receptor and natural antimicrobial content following treatment with low-dose mifepristone

Nitish Narvekar, Fatim Lakha, Hilary O D Critchley, Anna F Glasier, Alistair R W Williams, Riikka Leminen, Oskari Heikinheimo, Rodney W Kelly, David T Baird

Research output: Contribution to journalArticlepeer-review

Abstract

We have previously shown that the antigestagen mifepristone is contraceptive when given in a daily dose of 5 mg, po. Epidemiological studies suggest that gestagen-only contraceptives may increase the risk of transmission of human immunodeficiency virus (HIV) due to effects on the vaginal defenses to infection. We investigate the effects of mifepristone on vaginal thickness, steroid receptor and natural antimicrobial content and pharmacokinetics of mifepristone.
Original languageEnglish
Pages (from-to)271-80
Number of pages10
JournalContraception
Volume75
Issue number4
DOIs
Publication statusPublished - 2007

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