Changes in vaginal morphology, steroid receptor and natural antimicrobial content following treatment with low-dose mifepristone

Nitish Narvekar; Fatim Lakha; Hilary O D Critchley; Anna F Glasier; Alistair R W Williams; Riikka Leminen; Oskari Heikinheimo; Rodney W Kelly; David T Baird

doi:10.1016/j.contraception.2006.11.013

Changes in vaginal morphology, steroid receptor and natural antimicrobial content following treatment with low-dose mifepristone

Nitish Narvekar, Fatim Lakha, Hilary O D Critchley, Anna F Glasier, Alistair R W Williams, Riikka Leminen, Oskari Heikinheimo, Rodney W Kelly, David T Baird

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

We have previously shown that the antigestagen mifepristone is contraceptive when given in a daily dose of 5 mg, po. Epidemiological studies suggest that gestagen-only contraceptives may increase the risk of transmission of human immunodeficiency virus (HIV) due to effects on the vaginal defenses to infection. We investigate the effects of mifepristone on vaginal thickness, steroid receptor and natural antimicrobial content and pharmacokinetics of mifepristone.

Original language	English
Pages (from-to)	271-80
Number of pages	10
Journal	Contraception
Volume	75
Issue number	4
DOIs	https://doi.org/10.1016/j.contraception.2006.11.013
Publication status	Published - 2007

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10.1016/j.contraception.2006.11.013

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title = "Changes in vaginal morphology, steroid receptor and natural antimicrobial content following treatment with low-dose mifepristone",

abstract = "We have previously shown that the antigestagen mifepristone is contraceptive when given in a daily dose of 5 mg, po. Epidemiological studies suggest that gestagen-only contraceptives may increase the risk of transmission of human immunodeficiency virus (HIV) due to effects on the vaginal defenses to infection. We investigate the effects of mifepristone on vaginal thickness, steroid receptor and natural antimicrobial content and pharmacokinetics of mifepristone.",

author = "Nitish Narvekar and Fatim Lakha and Critchley, {Hilary O D} and Glasier, {Anna F} and Williams, {Alistair R W} and Riikka Leminen and Oskari Heikinheimo and Kelly, {Rodney W} and Baird, {David T}",

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AU - Narvekar, Nitish

AU - Lakha, Fatim

AU - Critchley, Hilary O D

AU - Glasier, Anna F

AU - Williams, Alistair R W

AU - Leminen, Riikka

AU - Heikinheimo, Oskari

AU - Kelly, Rodney W

AU - Baird, David T

PY - 2007

Y1 - 2007

N2 - We have previously shown that the antigestagen mifepristone is contraceptive when given in a daily dose of 5 mg, po. Epidemiological studies suggest that gestagen-only contraceptives may increase the risk of transmission of human immunodeficiency virus (HIV) due to effects on the vaginal defenses to infection. We investigate the effects of mifepristone on vaginal thickness, steroid receptor and natural antimicrobial content and pharmacokinetics of mifepristone.

AB - We have previously shown that the antigestagen mifepristone is contraceptive when given in a daily dose of 5 mg, po. Epidemiological studies suggest that gestagen-only contraceptives may increase the risk of transmission of human immunodeficiency virus (HIV) due to effects on the vaginal defenses to infection. We investigate the effects of mifepristone on vaginal thickness, steroid receptor and natural antimicrobial content and pharmacokinetics of mifepristone.

U2 - 10.1016/j.contraception.2006.11.013

DO - 10.1016/j.contraception.2006.11.013

M3 - Article

C2 - 17362705

SN - 0010-7824

VL - 75

SP - 271

EP - 280

JO - Contraception

JF - Contraception

IS - 4

ER -

Changes in vaginal morphology, steroid receptor and natural antimicrobial content following treatment with low-dose mifepristone

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