Characterisation of lesional infiltrates of dendritic cells and T cell subtypes during primary infestation of sheep with Psoroptes ovis, the sheep scab mite

A H M van den Broek, J F Huntley, A Mackellar, J Machell, M A Taylor, H R P Miller

Research output: Contribution to journalArticlepeer-review

Abstract

Earlier studies of cattle and sheep have demonstrated that Psoroptes ovis infestations provoke an intense immunoinflammatory response dominated by eosinophils accompanied by a substantial infiltrate of lymphocytes. However, the kinetics of the lymphocyte response and the subtypes involved have not been characterised. We employed two groups of sheep to investigate the early (1-21 days) and later (21-63 days) infiltration of lymphocyte subpopulations and dendritic cells in primary infestations of sheep with P. ovis. Immunohistochemistry indicated that by 4 days after infestation numbers of CD4+ and CD45RA+ cells in lesional skin had increased significantly (P
Original languageEnglish
Pages (from-to)141-50
Number of pages10
JournalVeterinary Immunology and Immunopathology
Volume105
Issue number1-2
DOIs
Publication statusPublished - 1 May 2005

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Biopsy
  • Dendritic Cells
  • Immunohistochemistry
  • Lymphocyte Count
  • Mite Infestations
  • Psoroptidae
  • Sheep
  • Sheep Diseases
  • Skin Diseases, Parasitic
  • T-Lymphocyte Subsets
  • T-Lymphocytes

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