Abstract
Earlier studies of cattle and sheep have demonstrated that Psoroptes ovis infestations provoke an intense immunoinflammatory response dominated by eosinophils accompanied by a substantial infiltrate of lymphocytes. However, the kinetics of the lymphocyte response and the subtypes involved have not been characterised. We employed two groups of sheep to investigate the early (1-21 days) and later (21-63 days) infiltration of lymphocyte subpopulations and dendritic cells in primary infestations of sheep with P. ovis. Immunohistochemistry indicated that by 4 days after infestation numbers of CD4+ and CD45RA+ cells in lesional skin had increased significantly (P
Original language | English |
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Pages (from-to) | 141-50 |
Number of pages | 10 |
Journal | Veterinary Immunology and Immunopathology |
Volume | 105 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - 1 May 2005 |
Keywords / Materials (for Non-textual outputs)
- Animals
- Biopsy
- Dendritic Cells
- Immunohistochemistry
- Lymphocyte Count
- Mite Infestations
- Psoroptidae
- Sheep
- Sheep Diseases
- Skin Diseases, Parasitic
- T-Lymphocyte Subsets
- T-Lymphocytes