Characterisation of Matrix Vesicles in Skeletal and Soft Tissue Mineralisation

L Cui, D A Houston, C Farquharson, V E MacRae

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The importance of matrix vesicles (MVs) have been repeatedly highlighted in the formation of cartilage, bone, and dentin since their discovery in 1967. These nano-vesicular structures, which are found in the extracellular matrix, are believed to be one of the sites of mineral nucleation that occurs in the organic matrix of the skeletal tissues. In the more recent years, there have been numerous reports on the observation of MV-like particles in calcified vascular tissues that could be playing a similar role. Therefore, here, we review the characteristics MVs possess that enable them to participate in mineral deposition. Additionally, we outline the content of skeletal tissue- and soft tissue-derived MVs, and discuss their key mineralisation mediators that could be targeted for future therapeutic use.

Original languageEnglish
Pages (from-to)147-158
Early online date9 Apr 2016
Publication statusE-pub ahead of print - 9 Apr 2016

Keywords / Materials (for Non-textual outputs)

  • matrix vesicles
  • vascular calcification
  • mineralisation
  • phosphate
  • mechanisms


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