Characterisation of tissue-type metabolic content in Secondary Progressive Multiple Sclerosis: a Magnetic Resonance Spectroscopic Imaging study

MS-SMART Trialists

doi:10.1007/s00415-018-8903-y

Characterisation of tissue-type metabolic content in Secondary Progressive Multiple Sclerosis: a Magnetic Resonance Spectroscopic Imaging study

MS-SMART Trialists

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Abstract

Proton Magnetic Resonance Spectroscopy yields metabolic information and has proved to be a useful addition to structural imaging in neurological diseases. We applied short-echo time Spectroscopic Imaging in a cohort of 42 patients with Secondary Progressive Multiple Sclerosis (SPMS). Linear modelling with respect to brain tissue type yielded metabolite levels that were significantly different in white matter lesions compared with normal appearing white matter, suggestive of higher myelin turnover (higher choline), higher metabolic rate (higher creatine) and increased glial activity (higher myo-inositol) within the lesions. These findings suggest that the lesions have ongoing cellular activity that is not
consistent with the usual assumption of ‘chronic’ lesions in SPMS, and may represent a target for repair therapies.

Original language	English
Journal	Journal of Neurology
Early online date	30 May 2018
DOIs	https://doi.org/10.1007/s00415-018-8903-y
Publication status	E-pub ahead of print - 30 May 2018

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10.1007/s00415-018-8903-y

Characterisation of tissue-type metabolic content...
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Ian Marshall
- Deanery of Clinical Sciences - UoE Retired Staff
Person: Affiliated Independent Researcher

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title = "Characterisation of tissue-type metabolic content in Secondary Progressive Multiple Sclerosis: a Magnetic Resonance Spectroscopic Imaging study",

abstract = "Proton Magnetic Resonance Spectroscopy yields metabolic information and has proved to be a useful addition to structural imaging in neurological diseases. We applied short-echo time Spectroscopic Imaging in a cohort of 42 patients with Secondary Progressive Multiple Sclerosis (SPMS). Linear modelling with respect to brain tissue type yielded metabolite levels that were significantly different in white matter lesions compared with normal appearing white matter, suggestive of higher myelin turnover (higher choline), higher metabolic rate (higher creatine) and increased glial activity (higher myo-inositol) within the lesions. These findings suggest that the lesions have ongoing cellular activity that is notconsistent with the usual assumption of {\textquoteleft}chronic{\textquoteright} lesions in SPMS, and may represent a target for repair therapies.",

author = "{MS-SMART Trialists} and Ian Marshall and Michael Thrippleton and Mark Bastin and Daisy Mollison and Dickie, {David Alexander} and Francesca Chappell and Scott Semple and Annette Cooper and Sue Pavitt and Gavin Giovannoni and {Gandini Wheeler-Kingshott}, {Claudia AM} and Solanky, {Bhavana S} and Christopher Weir and Nigel Stallard and Clive Hawkins and Basil Sharrack and Jeremy Chataway and Peter Connick and Siddharthan Chandran",

year = "2018",

month = may,

day = "30",

doi = "10.1007/s00415-018-8903-y",

language = "English",

journal = "Journal of Neurology",

issn = "0340-5354",

publisher = "D. Steinkopff-Verlag",

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TY - JOUR

T1 - Characterisation of tissue-type metabolic content in Secondary Progressive Multiple Sclerosis: a Magnetic Resonance Spectroscopic Imaging study

AU - MS-SMART Trialists

AU - Marshall, Ian

AU - Thrippleton, Michael

AU - Bastin, Mark

AU - Mollison, Daisy

AU - Dickie, David Alexander

AU - Chappell, Francesca

AU - Semple, Scott

AU - Cooper, Annette

AU - Pavitt, Sue

AU - Giovannoni, Gavin

AU - Gandini Wheeler-Kingshott, Claudia AM

AU - Solanky, Bhavana S

AU - Weir, Christopher

AU - Stallard, Nigel

AU - Hawkins, Clive

AU - Sharrack, Basil

AU - Chataway, Jeremy

AU - Connick, Peter

AU - Chandran, Siddharthan

PY - 2018/5/30

Y1 - 2018/5/30

N2 - Proton Magnetic Resonance Spectroscopy yields metabolic information and has proved to be a useful addition to structural imaging in neurological diseases. We applied short-echo time Spectroscopic Imaging in a cohort of 42 patients with Secondary Progressive Multiple Sclerosis (SPMS). Linear modelling with respect to brain tissue type yielded metabolite levels that were significantly different in white matter lesions compared with normal appearing white matter, suggestive of higher myelin turnover (higher choline), higher metabolic rate (higher creatine) and increased glial activity (higher myo-inositol) within the lesions. These findings suggest that the lesions have ongoing cellular activity that is notconsistent with the usual assumption of ‘chronic’ lesions in SPMS, and may represent a target for repair therapies.

AB - Proton Magnetic Resonance Spectroscopy yields metabolic information and has proved to be a useful addition to structural imaging in neurological diseases. We applied short-echo time Spectroscopic Imaging in a cohort of 42 patients with Secondary Progressive Multiple Sclerosis (SPMS). Linear modelling with respect to brain tissue type yielded metabolite levels that were significantly different in white matter lesions compared with normal appearing white matter, suggestive of higher myelin turnover (higher choline), higher metabolic rate (higher creatine) and increased glial activity (higher myo-inositol) within the lesions. These findings suggest that the lesions have ongoing cellular activity that is notconsistent with the usual assumption of ‘chronic’ lesions in SPMS, and may represent a target for repair therapies.

U2 - 10.1007/s00415-018-8903-y

DO - 10.1007/s00415-018-8903-y

M3 - Article

JO - Journal of Neurology

JF - Journal of Neurology

SN - 0340-5354

ER -

Characterisation of tissue-type metabolic content in Secondary Progressive Multiple Sclerosis: a Magnetic Resonance Spectroscopic Imaging study

Abstract

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Ian Marshall

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