Characterization of the proteome, diseases and evolution of the human postsynaptic density

Alex Bayes; Louie Van De Lagemaat; Mark O. Collins; Mike D. R. Croning; Ian R. Whittle; Jyoti S. Choudhary; Seth G. N. Grant

doi:10.1038/nn.2719

Characterization of the proteome, diseases and evolution of the human postsynaptic density

Alex Bayes, Louie Van De Lagemaat, Mark O. Collins, Mike D. R. Croning, Ian R. Whittle, Jyoti S. Choudhary, Seth G. N. Grant

Research output: Contribution to journal › Article › peer-review

Abstract

We isolated the postsynaptic density from human neocortex (hPSD) and identified 1,461 proteins. hPSD mutations cause 133 neurological and psychiatric diseases and were enriched in cognitive, affective and motor phenotypes underpinned by sets of genes. Strong protein sequence conservation in mammalian lineages, particularly in hub proteins, indicates conserved function and organization in primate and rodent models. The hPSD is an important structure for nervous system disease and behavior.

Original language	English
Pages (from-to)	19-21
Number of pages	3
Journal	Nature Neuroscience
Volume	14
Issue number	1
Early online date	19 Dec 2010
DOIs	https://doi.org/10.1038/nn.2719
Publication status	Published - Jan 2011

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10.1038/nn.2719

Characterization of the proteome, diseases and evolution of the human postsynaptic density
Published in final edited form as: Nat Neurosci. 2011 January ; 14(1): 19–21. doi:10.1038/nn.2719.
Accepted author manuscript, 621 KB

http://www.nature.com/neuro/journal/v14/n1/full/nn.2719.html

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Characterization of the proteome, diseases and evolution of the human postsynaptic density

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