Characterizing mild cognitive impairment in incident Parkinson disease: the ICICLE-PD study

ICICLE-PD Study Group, Alison J Yarnall, David P Breen, Gordon W Duncan, Tien K Khoo, Shirley Y Coleman, Michael J Firbank, Cristina Nombela, Sophie Winder-Rhodes, Jonathan R Evans, James B Rowe, Brit Mollenhauer, Niels Kruse, Gavin Hudson, Patrick F Chinnery, John T O'Brien, Trevor W Robbins, Keith Wesnes, David J Brooks, Roger A BarkerDavid J Burn

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

OBJECTIVE: To describe the frequency of mild cognitive impairment (MCI) in Parkinson disease (PD) in a cohort of newly diagnosed incident PD cases and the associations with a panel of biomarkers.

METHODS: Between June 2009 and December 2011, 219 subjects with PD and 99 age-matched controls participated in clinical and neuropsychological assessments as part of a longitudinal observational study. Consenting individuals underwent structural MRI, lumbar puncture, and genotyping for common variants of COMT, MAPT, SNCA, BuChE, EGF, and APOE. PD-MCI was defined with reference to the new Movement Disorder Society criteria.

RESULTS: The frequency of PD-MCI was 42.5% using level 2 criteria at 1.5 SDs below normative values. Memory impairment was the most common domain affected, with 15.1% impaired at 1.5 SDs. Depression scores were significantly higher in those with PD-MCI than the cognitively normal PD group. A significant correlation was found between visual Pattern Recognition Memory and cerebrospinal β-amyloid 1-42 levels (β standardized coefficient = 0.350; p = 0.008) after controlling for age and education in a linear regression model, with lower β-amyloid 1-42 and 1-40 levels observed in those with PD-MCI. Voxel-based morphometry did not reveal any areas of significant gray matter loss in participants with PD-MCI compared with controls, and no specific genotype was associated with PD-MCI at the 1.5-SD threshold.

CONCLUSIONS: In a large cohort of newly diagnosed PD participants, PD-MCI is common and significantly correlates with lower cerebrospinal β-amyloid 1-42 and 1-40 levels. Future longitudinal studies should enable us to determine those measures predictive of cognitive decline.

Original languageEnglish
Pages (from-to)308-16
Number of pages9
JournalNeurology
Volume82
Issue number4
Early online date20 Dec 2013
DOIs
Publication statusPublished - 28 Jan 2014

Keywords / Materials (for Non-textual outputs)

  • Aged
  • Aged, 80 and over
  • Amyloid beta-Peptides
  • Case-Control Studies
  • Female
  • Humans
  • Intermediate Filament Proteins
  • Male
  • Middle Aged
  • Mild Cognitive Impairment
  • Neuropsychological Tests
  • Parkinson Disease
  • Peptide Fragments
  • Retrospective Studies
  • Severity of Illness Index
  • tau Proteins

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