TY - JOUR
T1 - Charge dynamics of amino acids fingerprints and the effect of density on FinFET-based Electrolyte-gated sensor
AU - Kumar, Naveen
AU - García, César Pascual
AU - Dixit, Ankit
AU - Rezaei, Ali
AU - Georgiev, Vihar
N1 - Publisher Copyright:
© 2023 The Author(s)
PY - 2023/12/1
Y1 - 2023/12/1
N2 - This work presents the charge dynamics and the effect of the density of amino acids on a sensing surface with the help of analytical modelling. We have implemented an in-house simulator incorporating the Gouy-Chapman-Stern and Site-Binding model to capture the perturbations in the proton affinity of reactive sites with the variation of amino acid density over a sensing surface. The results of the models are explained for Alanine, Glutamic Acid and Histidine with their α-carboxylic terminal immobilized on the sensor surface. The results show that an increase in amino acid density on the sensing surface over a certain limit deviates the fingerprints of the proton affinity away from the affinity of the reactive sites of individual amino acids. The effect of different electrolyte concentrations on steric hindrance is also captured for Alanine and Glutamic Acid. Finally, we used a junctionless FinFET to model unique signatures of amino acids down to a single molecule.
AB - This work presents the charge dynamics and the effect of the density of amino acids on a sensing surface with the help of analytical modelling. We have implemented an in-house simulator incorporating the Gouy-Chapman-Stern and Site-Binding model to capture the perturbations in the proton affinity of reactive sites with the variation of amino acid density over a sensing surface. The results of the models are explained for Alanine, Glutamic Acid and Histidine with their α-carboxylic terminal immobilized on the sensor surface. The results show that an increase in amino acid density on the sensing surface over a certain limit deviates the fingerprints of the proton affinity away from the affinity of the reactive sites of individual amino acids. The effect of different electrolyte concentrations on steric hindrance is also captured for Alanine and Glutamic Acid. Finally, we used a junctionless FinFET to model unique signatures of amino acids down to a single molecule.
U2 - 10.1016/j.sse.2023.108789
DO - 10.1016/j.sse.2023.108789
M3 - Article
AN - SCOPUS:85174316963
SN - 0038-1101
VL - 210
SP - 1
EP - 3
JO - Solid-State Electronics
JF - Solid-State Electronics
M1 - 108789
ER -