Charting the Chemical Reaction Space around a Multicomponent Combination: Controlled Access to a Diverse Set of Biologically Relevant Scaffolds

Pau Nadal rodríguez, Ouldouz Ghashghaei, Anna M. Schoepf, Sam Benson, Marc Vendrell, Rodolfo Lavilla

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Charting the chemical reaction space around the combination of carbonyls, amines, and isocyanoacetates allows the description of new multicomponent processes leading to a variety of unsaturated imidazolone scaffolds. The resulting compounds display the chromophore of the green fluorescent protein and the core of the natural product coelenterazine. Despite the competitive nature of the pathways involved, general protocols provide selective access to the desired chemotypes. Moreover, we describe unprecedented reactivity at the C-2 position of the imidazolone core to directly afford C, S, and N-derivatives featuring natural products (e.g. leucettamines), potent kinase inhibitors, and fluorescent probes with suitable optical and biological profiles.
Original languageEnglish
JournalAngewandte Chemie International Edition
DOIs
Publication statusPublished - 16 May 2023

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