Chemical Constituents of Cordia latifolia and Their Nematicidal Activity

Sabira Begum, Sobiya Perwaiz, Bina S. Siddiqui*, Shazia Khan, Shahina Fayyaz, Musarrat Ramzan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Following nematicidal activity-guided isolation studies on the fruits, bark, and leaves of Cordia latifolia, two new constituents, cordinoic acid (=11-oxours-12-ene-23,28-dioic acid; 1) and cordicilin (=2-{[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-3-[4-hydroxy-3-(stearoyloxy)phenyl]propanoic acid; 2) were isolated from the stem and leaves, respectively, together with nine known compounds, namely cordioic and cordifolic acid from the stem bark, latifolicin A-D and rosmarinic acid from the fruits, and cordinol and cordicinol from the leaves. Their structures were determined by means of spectroscopic analyses including 1D- and 2D-NMR techniques. The nematicidal activities of these constituents were determined against the root-knot nematode Meloidogyne incognita. Hundred percent mortality was caused by all of these after 72 h at a 0.125% concentration. Compound 1 and cordioic acid were most active and caused 100% mortality after 24 h at a 0.50% concentration. Furthermore, compound 2, the ester of rosemarinic acid, was found to be more active than the free acid.

Original languageEnglish
Pages (from-to)850-861
Number of pages12
JournalChemistry and Biodiversity
Volume8
Issue number5
Publication statusPublished - May 2011

Keywords

  • LITHOSPERMUM-RUDERALE
  • POLYPHENOLIC ACIDS
  • OBLIQUA
  • ROOTS
  • FRUITS
  • PLANTS
  • SEEDS
  • BARK

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