Projects per year
Results: We found distinct, largely non-overlapping sets of compounds that rectify nuclear size changes for each tumor cell line. Several classes of compounds including e.g. serotonin uptake inhibitors, cyclo-oxygenase inhibitors, beta-adrenergic receptor agonists, and Na+/K+ ATPase inhibitors displayed coherent nuclear size phenotypes focused on a particular cell line or across cell lines and treatment conditions. Several compounds from classes far afield from current chemotherapy regimens were also identified. Seven nuclear size-rectifying compounds selected for further investigation all inhibited cell migration and/or invasion.
Conclusions: Our study provides (a) proof-of-concept that nuclear size might be a valuable target to reduce cell migration/invasion in cancer treatment, and (b) the most thorough collection of tool compounds to date reversing nuclear size changes specific to individual cancer-type cell lines. Although these compounds still need to be tested in primary cancer cells, the cell line-specific nuclear size and migration/invasion responses to particular drug classes suggests that cancer type-specific nuclear size rectifiers may help reduce metastatic spread.
- nuclear size regulation
- cell migration
- chemical screen
FingerprintDive into the research topics of 'Chemical interrogation of nuclear size identifies compounds with cancer cell line specific effects on migration and invasion'. Together they form a unique fingerprint.
1/08/18 → 31/07/22
1/10/11 → 30/04/17