Projects per year
Abstract
Immunomodulatory agents represent one of the most promising strategies for enhancing tissue regeneration without the side effects of traditional drug-based therapies. Tissue repair depends largely on macrophages, making them ideal targets for proregenerative therapies. However, given the multiple roles of macrophages in tissue homeostasis, small molecule drugs must be only active in very specific subpopulations. In this work, we have developed the first prodrug–fluorophore conjugates able to discriminate closely related subpopulations of macrophages (i.e., proinflammatory M1 vs anti-inflammatory M2 macrophages), and employed them to deplete M1 macrophages in vivo without affecting other cell populations. Selective intracellular activation and drug release enabled simultaneous fluorescence cell tracking and ablation of M1 macrophages in vivo, with the concomitant rescue of a proregenerative phenotype. Ex vivo assays in human monocyte-derived macrophages validate the translational potential of this novel platform to develop chemical immunomodulatory agents as targeted therapies for immune-related diseases.
Original language | English |
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Pages (from-to) | 995-1005 |
Number of pages | 11 |
Journal | ACS Central Science |
Volume | 3 |
Issue number | 9 |
Early online date | 30 Aug 2017 |
DOIs | |
Publication status | Published - 27 Sep 2017 |
Keywords
- Journal Article
Fingerprint
Dive into the research topics of 'Chemical modulation of in vivo macrophage function with subpopulation-specific fluorescent prodrug conjugates'. Together they form a unique fingerprint.Projects
- 3 Finished
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Development of phloem-mobile xenobiotics with enhanced transport properties
Oparka, K.
UK industry, commerce and public corporations
1/09/15 → 30/06/19
Project: Research
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ENDOIMAGE - Activatable Fluorescent Probes as Smart Diagnostic Tools for Microendoscopy Imaging
1/08/13 → 31/07/17
Project: Research
Profiles
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Marc Vendrell Escobar
- Deanery of Clinical Sciences - Personal Chair Translational Chemistry & Biomedical Imaging
- Centre for Inflammation Research
Person: Academic: Research Active