Chemoselective nitro reduction and hydroamination using a single iron catalyst

Stephen Thomas, Michael Shaver, Kailong Zhu

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The reduction and reductive addition (formal hydroamination) of functionalised nitroarenes is reported using a simple and bench-stable iron(III) catalyst and silane. The reduction is chemoselective for nitro groups over an array of reactive functionalities (ketone, ester, amide, nitrile, sulfonyl and aryl halide). The high activity of this earth-abundant metal catalyst also facilitates a follow-on reaction in the reductive addition of nitroarenes to alkenes, giving efficient formal hydroamination of olefins under mild conditions. Both reactions offer significant improvements in catalytic activity and chemoselectivity and the utility of these catalysts in facilitating two challenging reactions supports an important mechanistic overlap.
Original languageEnglish
JournalChemical Science
Early online date26 Jan 2016
Publication statusE-pub ahead of print - 26 Jan 2016


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