Chimpanzee reservoirs of pandemic and nonpandemic HIV-1

Brandon F. Keele, Fran Van Heuverswyn, Yingying Li, Elizabeth Bailes, Jun Takehisa, Mario L. Santiago, Frederic Bibollet-Ruche, Yalu Chen, Louise V. Wain, Florian Liegeois, Severin Loul, Eitel Mpoudi Ngole, Yanga Bienvenue, Eric Delaporte, John F. Y. Brookfield, Paul M. Sharp, George M. Shaw, Martine Peeters, Beatrice H. Hahn

Research output: Contribution to journalArticlepeer-review

Abstract

Human immunodeficiency virus type 1 (HIV-1), the cause of human acquired immunodeficiency syndrome ( AIDS), is a zoonotic infection of staggering proportions and social impact. Yet uncertainty persists regarding its natural reservoir. The virus most closely related to HIV-1 is a simian immunodeficiency virus ( SIV) thus far identified only in captive members of the chimpanzee subspecies Pan troglodytes troglodytes. Here we report the detection of SIVcpz antibodies and nucleic acids in fecal samples from wild-living P.t. troglodytes apes in southern Cameroon, where prevalence rates in some communities reached 29 to 35%. By sequence analysis of endemic SIVcpz strains, we could trace the origins of pandemic ( group M) and nonpandemic ( group N) HIV-1 to distinct, geographically isolated chimpanzee communities. These findings establish P. t. troglodytes as a natural reservoir of HIV-1.

Original languageEnglish
Pages (from-to)523-526
Number of pages4
JournalScience
Volume313
Issue number5786
DOIs
Publication statusPublished - 28 Jul 2006

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