Chitosan hydrogel micro-bio-devices with complex capillary patterns via reactive-diffusive self-assembly

Vahid Adibnia; Marziye Mirbagheri; Pierre-Luc Latreille; Jimmy Faivre; Bruno Cecyre; Jean-Francois Bouchard; Vincent Arnaud Martinez; Thierry Delair; Laurent David; Dae Kun Hwang; Xavier Banquy

doi:10.1016/j.actbio.2019.08.037

Chitosan hydrogel micro-bio-devices with complex capillary patterns via reactive-diffusive self-assembly

Vahid Adibnia, Marziye Mirbagheri, Pierre-Luc Latreille, Jimmy Faivre, Bruno Cecyre, Jean-Francois Bouchard, Vincent Arnaud Martinez, Thierry Delair, Laurent David, Dae Kun Hwang, Xavier Banquy

School of Physics and Astronomy

Research output: Contribution to journal › Article › peer-review

Abstract

We present chitosan hydrogel microfluidic devices with self-assembled complex microcapillary patterns, conveniently formed by a diffusion-reaction process. These patterns in chitosan hydrogels are formed by a single-step procedure involving diffusion of a gelation agent into the polymer solution inside a microfluidic channel. By changing the channel geometry, it is demonstrated how to control capillary length, trajectory and branching. Diffusion of nanoparticles (NPs) in the capillary network is used as a model to effectively mimic the transport of nano-objects in vascularized tissues. Gold NPs diffusion is measured locally in the hydrogel chips, and during their two-step transport through the capillaries to the gel matrix and eventually to embedded cell clusters in the gel. In addition, the quantitative analyses reported in this study provide novel opportunities for theoretical investigation of capillary formation and propagation during diffusive gelation of biopolymers.

Original language	English
Pages (from-to)	211-219
Number of pages	9
Journal	Acta Biomaterialia
Volume	99
Early online date	29 Aug 2019
DOIs	https://doi.org/10.1016/j.actbio.2019.08.037
Publication status	Published - 1 Nov 2019

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Adibnia et al 2019Accepted author manuscript, 6.32 MB

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Adibnia, Vahid ; Mirbagheri, Marziye ; Latreille, Pierre-Luc ; Faivre, Jimmy ; Cecyre, Bruno ; Bouchard, Jean-Francois ; Martinez, Vincent Arnaud ; Delair, Thierry ; David, Laurent ; Hwang, Dae Kun ; Banquy, Xavier. / Chitosan hydrogel micro-bio-devices with complex capillary patterns via reactive-diffusive self-assembly. In: Acta Biomaterialia. 2019 ; Vol. 99. pp. 211-219.

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title = "Chitosan hydrogel micro-bio-devices with complex capillary patterns via reactive-diffusive self-assembly",

abstract = "We present chitosan hydrogel microfluidic devices with self-assembled complex microcapillary patterns, conveniently formed by a diffusion-reaction process. These patterns in chitosan hydrogels are formed by a single-step procedure involving diffusion of a gelation agent into the polymer solution inside a microfluidic channel. By changing the channel geometry, it is demonstrated how to control capillary length, trajectory and branching. Diffusion of nanoparticles (NPs) in the capillary network is used as a model to effectively mimic the transport of nano-objects in vascularized tissues. Gold NPs diffusion is measured locally in the hydrogel chips, and during their two-step transport through the capillaries to the gel matrix and eventually to embedded cell clusters in the gel. In addition, the quantitative analyses reported in this study provide novel opportunities for theoretical investigation of capillary formation and propagation during diffusive gelation of biopolymers.",

author = "Vahid Adibnia and Marziye Mirbagheri and Pierre-Luc Latreille and Jimmy Faivre and Bruno Cecyre and Jean-Francois Bouchard and Martinez, {Vincent Arnaud} and Thierry Delair and Laurent David and Hwang, {Dae Kun} and Xavier Banquy",

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doi = "10.1016/j.actbio.2019.08.037",

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journal = "Acta Biomaterialia",

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Chitosan hydrogel micro-bio-devices with complex capillary patterns via reactive-diffusive self-assembly. / Adibnia, Vahid; Mirbagheri, Marziye; Latreille, Pierre-Luc; Faivre, Jimmy; Cecyre, Bruno; Bouchard, Jean-Francois; Martinez, Vincent Arnaud; Delair, Thierry; David, Laurent; Hwang, Dae Kun; Banquy, Xavier.

In: Acta Biomaterialia, Vol. 99, 01.11.2019, p. 211-219.

Research output: Contribution to journal › Article › peer-review

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AU - Adibnia, Vahid

AU - Mirbagheri, Marziye

AU - Latreille, Pierre-Luc

AU - Faivre, Jimmy

AU - Cecyre, Bruno

AU - Bouchard, Jean-Francois

AU - Martinez, Vincent Arnaud

AU - Delair, Thierry

AU - David, Laurent

AU - Hwang, Dae Kun

AU - Banquy, Xavier

PY - 2019/11/1

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AB - We present chitosan hydrogel microfluidic devices with self-assembled complex microcapillary patterns, conveniently formed by a diffusion-reaction process. These patterns in chitosan hydrogels are formed by a single-step procedure involving diffusion of a gelation agent into the polymer solution inside a microfluidic channel. By changing the channel geometry, it is demonstrated how to control capillary length, trajectory and branching. Diffusion of nanoparticles (NPs) in the capillary network is used as a model to effectively mimic the transport of nano-objects in vascularized tissues. Gold NPs diffusion is measured locally in the hydrogel chips, and during their two-step transport through the capillaries to the gel matrix and eventually to embedded cell clusters in the gel. In addition, the quantitative analyses reported in this study provide novel opportunities for theoretical investigation of capillary formation and propagation during diffusive gelation of biopolymers.

U2 - 10.1016/j.actbio.2019.08.037

DO - 10.1016/j.actbio.2019.08.037

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