TY - JOUR
T1 - Chitosan hydrogel micro-bio-devices with complex capillary patterns via reactive-diffusive self-assembly
AU - Adibnia, Vahid
AU - Mirbagheri, Marziye
AU - Latreille, Pierre-Luc
AU - Faivre, Jimmy
AU - Cecyre, Bruno
AU - Bouchard, Jean-Francois
AU - Martinez, Vincent Arnaud
AU - Delair, Thierry
AU - David, Laurent
AU - Hwang, Dae Kun
AU - Banquy, Xavier
PY - 2019/11/1
Y1 - 2019/11/1
N2 - We present chitosan hydrogel microfluidic devices with self-assembled complex microcapillary patterns, conveniently formed by a diffusion-reaction process. These patterns in chitosan hydrogels are formed by a single-step procedure involving diffusion of a gelation agent into the polymer solution inside a microfluidic channel. By changing the channel geometry, it is demonstrated how to control capillary length, trajectory and branching. Diffusion of nanoparticles (NPs) in the capillary network is used as a model to effectively mimic the transport of nano-objects in vascularized tissues. Gold NPs diffusion is measured locally in the hydrogel chips, and during their two-step transport through the capillaries to the gel matrix and eventually to embedded cell clusters in the gel. In addition, the quantitative analyses reported in this study provide novel opportunities for theoretical investigation of capillary formation and propagation during diffusive gelation of biopolymers.
AB - We present chitosan hydrogel microfluidic devices with self-assembled complex microcapillary patterns, conveniently formed by a diffusion-reaction process. These patterns in chitosan hydrogels are formed by a single-step procedure involving diffusion of a gelation agent into the polymer solution inside a microfluidic channel. By changing the channel geometry, it is demonstrated how to control capillary length, trajectory and branching. Diffusion of nanoparticles (NPs) in the capillary network is used as a model to effectively mimic the transport of nano-objects in vascularized tissues. Gold NPs diffusion is measured locally in the hydrogel chips, and during their two-step transport through the capillaries to the gel matrix and eventually to embedded cell clusters in the gel. In addition, the quantitative analyses reported in this study provide novel opportunities for theoretical investigation of capillary formation and propagation during diffusive gelation of biopolymers.
U2 - 10.1016/j.actbio.2019.08.037
DO - 10.1016/j.actbio.2019.08.037
M3 - Article
VL - 99
SP - 211
EP - 219
JO - Acta Biomaterialia
JF - Acta Biomaterialia
SN - 1742-7061
ER -