Chloromethyl-triazole: a new motif for site-selective pseudo-acylation of proteins

Richard C. Brewster, Georgina C. Gavins, Barbara Günthardt, Sarah Farr, Kimberly M. Webb, Philipp Voigt, Alison N. Hulme

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Rapid, site-selective modification of cysteine residues with chloromethyl-triazole derivatives generates pseudo-acyl sLys motifs, mimicking important post-translational modifications. Near-native biotinylation of peptide and protein substrates is shown to be site-selective and modified histone H4 retains functional activity.
Original languageEnglish
Pages (from-to)12230-12232
Number of pages3
JournalChemical Communications
Volume52
Issue number82
Early online date13 Sept 2016
DOIs
Publication statusE-pub ahead of print - 13 Sept 2016

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