Chloromethyl-triazole: a new motif for site-selective pseudo-acylation of proteins

Richard C. Brewster, Georgina C. Gavins, Barbara Günthardt, Sarah Farr, Kimberly M. Webb, Philipp Voigt, Alison N. Hulme

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Rapid, site-selective modification of cysteine residues with chloromethyl-triazole derivatives generates pseudo-acyl sLys motifs, mimicking important post-translational modifications. Near-native biotinylation of peptide and protein substrates is shown to be site-selective and modified histone H4 retains functional activity.
Original languageEnglish
Pages (from-to)12230-12232
Number of pages3
JournalChemical Communications
Issue number82
Early online date13 Sept 2016
Publication statusE-pub ahead of print - 13 Sept 2016


Dive into the research topics of 'Chloromethyl-triazole: a new motif for site-selective pseudo-acylation of proteins'. Together they form a unique fingerprint.

Cite this