Choline and Creatine Are Not Reliable Denominators for Calculating Metabolite Ratios in Acute Ischemic Stroke

S. M. Maniega, V. Cvoro, P. A. Armitage, I. Marshall, M. E. Bastin, J. M. Wardlaw

Research output: Contribution to journal › Article › peer-review

Abstract

Background and Purpose-Choline and creatine are commonly used as denominators for other metabolites in ischemic stroke spectroscopy, assuming that they do not change. We investigated their concentration variation over time after stroke.

Methods-Choline and creatine concentrations were measured by proton MR spectroscopic imaging in 51 patients at 5 times up to 3 months after stroke.

Results-Choline and creatine levels changed significantly in the ischemic region. Choline was significantly reduced during the first 2 weeks after stroke onset (P = 0.034). Creatine was significantly reduced during the whole period of the study (P = 0.011).

Conclusion-Choline and creatine concentrations are not reliable denominators for metabolite ratios in acute stroke because their levels vary significantly in ischemic brain regions.
Original languageEnglish
Pages (from-to)2467-2469
Number of pages3
JournalStroke
Volume39
Issue number9
DOIs
Publication statusPublished - Sep 2008

Keywords

  • metabolic ratios
  • MR spectroscopy
  • acute ischemic stroke

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