Choline and Creatine Are Not Reliable Denominators for Calculating Metabolite Ratios in Acute Ischemic Stroke

S. M. Maniega; V. Cvoro; P. A. Armitage; I. Marshall; M. E. Bastin; J. M. Wardlaw

doi:10.1161/STROKEAHA.107.507020

Choline and Creatine Are Not Reliable Denominators for Calculating Metabolite Ratios in Acute Ischemic Stroke

S. M. Maniega, V. Cvoro, P. A. Armitage, I. Marshall, M. E. Bastin, J. M. Wardlaw

Research output: Contribution to journal › Article › peer-review

Abstract

Background and Purpose-Choline and creatine are commonly used as denominators for other metabolites in ischemic stroke spectroscopy, assuming that they do not change. We investigated their concentration variation over time after stroke.

Methods-Choline and creatine concentrations were measured by proton MR spectroscopic imaging in 51 patients at 5 times up to 3 months after stroke.

Results-Choline and creatine levels changed significantly in the ischemic region. Choline was significantly reduced during the first 2 weeks after stroke onset (P = 0.034). Creatine was significantly reduced during the whole period of the study (P = 0.011).

Conclusion-Choline and creatine concentrations are not reliable denominators for metabolite ratios in acute stroke because their levels vary significantly in ischemic brain regions.

Original language	English
Pages (from-to)	2467-2469
Number of pages	3
Journal	Stroke
Volume	39
Issue number	9
DOIs	https://doi.org/10.1161/STROKEAHA.107.507020
Publication status	Published - Sep 2008

Keywords

metabolic ratios
MR spectroscopy
acute ischemic stroke

Access to Document

10.1161/STROKEAHA.107.507020

http://stroke.ahajournals.org/content/39/9/2467

Cite this

@article{61b528d2fa8045ccbe06a9fc3b08fc84,

title = "Choline and Creatine Are Not Reliable Denominators for Calculating Metabolite Ratios in Acute Ischemic Stroke",

abstract = "Background and Purpose-Choline and creatine are commonly used as denominators for other metabolites in ischemic stroke spectroscopy, assuming that they do not change. We investigated their concentration variation over time after stroke.Methods-Choline and creatine concentrations were measured by proton MR spectroscopic imaging in 51 patients at 5 times up to 3 months after stroke.Results-Choline and creatine levels changed significantly in the ischemic region. Choline was significantly reduced during the first 2 weeks after stroke onset (P = 0.034). Creatine was significantly reduced during the whole period of the study (P = 0.011).Conclusion-Choline and creatine concentrations are not reliable denominators for metabolite ratios in acute stroke because their levels vary significantly in ischemic brain regions.",

keywords = "metabolic ratios, MR spectroscopy, acute ischemic stroke",

author = "Maniega, {S. M.} and V. Cvoro and Armitage, {P. A.} and I. Marshall and Bastin, {M. E.} and Wardlaw, {J. M.}",

year = "2008",

month = sep,

doi = "10.1161/STROKEAHA.107.507020",

language = "English",

volume = "39",

pages = "2467--2469",

journal = "Stroke",

issn = "0039-2499",

publisher = "Lippincott Williams & Wilkins",

number = "9",

}

TY - JOUR

T1 - Choline and Creatine Are Not Reliable Denominators for Calculating Metabolite Ratios in Acute Ischemic Stroke

AU - Maniega, S. M.

AU - Cvoro, V.

AU - Armitage, P. A.

AU - Marshall, I.

AU - Bastin, M. E.

AU - Wardlaw, J. M.

PY - 2008/9

Y1 - 2008/9

N2 - Background and Purpose-Choline and creatine are commonly used as denominators for other metabolites in ischemic stroke spectroscopy, assuming that they do not change. We investigated their concentration variation over time after stroke.Methods-Choline and creatine concentrations were measured by proton MR spectroscopic imaging in 51 patients at 5 times up to 3 months after stroke.Results-Choline and creatine levels changed significantly in the ischemic region. Choline was significantly reduced during the first 2 weeks after stroke onset (P = 0.034). Creatine was significantly reduced during the whole period of the study (P = 0.011).Conclusion-Choline and creatine concentrations are not reliable denominators for metabolite ratios in acute stroke because their levels vary significantly in ischemic brain regions.

AB - Background and Purpose-Choline and creatine are commonly used as denominators for other metabolites in ischemic stroke spectroscopy, assuming that they do not change. We investigated their concentration variation over time after stroke.Methods-Choline and creatine concentrations were measured by proton MR spectroscopic imaging in 51 patients at 5 times up to 3 months after stroke.Results-Choline and creatine levels changed significantly in the ischemic region. Choline was significantly reduced during the first 2 weeks after stroke onset (P = 0.034). Creatine was significantly reduced during the whole period of the study (P = 0.011).Conclusion-Choline and creatine concentrations are not reliable denominators for metabolite ratios in acute stroke because their levels vary significantly in ischemic brain regions.

KW - metabolic ratios

KW - MR spectroscopy

KW - acute ischemic stroke

UR - http://www.scopus.com/inward/record.url?scp=52449098692&partnerID=8YFLogxK

U2 - 10.1161/STROKEAHA.107.507020

DO - 10.1161/STROKEAHA.107.507020

M3 - Article

VL - 39

SP - 2467

EP - 2469

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 9

ER -

Choline and Creatine Are Not Reliable Denominators for Calculating Metabolite Ratios in Acute Ischemic Stroke

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Row Fogo Charitable Trust Funds

Scottish e-Science Data, Information and Knowledge Transformation (eDIKT) Centre

Can magnetic resonance spectroscopic imaging guide acute ischaemic stroke treatment?

Cite this

Choline and Creatine Are Not Reliable Denominators for Calculating Metabolite Ratios in Acute Ischemic Stroke

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Projects

Row Fogo Charitable Trust Funds

Scottish e-Science Data, Information and Knowledge Transformation (eDIKT) Centre

Can magnetic resonance spectroscopic imaging guide acute ischaemic stroke treatment?

Cite this