Cholinergic modulation of hippocampal cells and circuits

S.R. Cobb, C.H. Davies

Research output: Contribution to journalArticlepeer-review

Abstract

Septo-hippocampal cholinergic fibres ramify extensively throughout the hippocampal formation to release acetylcholine upon a diverse range of muscarinic and nicotinic acetylcholine receptors that are differentially expressed by distinct populations of neurones. The resultant modulation of cellular excitability and synaptic transmission within hippocampal circuits underlies the ability of acetylcholine to influence the dynamic properties of the hippocampal network and results in the emergence of a range of stable oscillatory network states. Recent findings suggest a multitude of actions contribute to the oscillogenic properties of acetylcholine which are principally induced by activation of muscarinic receptors but also regulated through activation of nicotinic receptor subtypes.
Original languageEnglish
Pages (from-to)81-88
Number of pages8
JournalJournal of Physiology
Volume562
Issue number1
DOIs
Publication statusPublished - 1 Jan 2005

Fingerprint

Dive into the research topics of 'Cholinergic modulation of hippocampal cells and circuits'. Together they form a unique fingerprint.

Cite this