CHOP-based chemotherapy is as effective as alternating PEEC/CHOP chemotherapy in a randomised trial in high-grade non-Hodgkin's lymphoma. Scotland and Newcastle Lymphoma Group

D A Cameron, J M White, S J Proctor, R J Prescott, R C Leonard, B Angus, M K Cook, P J Dawes, Alice Dawson, R G Evans, M J Galloway, A L Harris, A Heppleston, C H Horne, A S Krajewski, A L Lennard, A M Lessells, H H Lucraft, J B MacGillivray, M J MackieA C Parker, J T Roberts, P R Taylor, W D Thompson

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Abstract

The aim of this study was to test whether survival for patients with high-grade non-Hodgkin's lymphoma (NHL) can be improved with a non-cross-resistant regimen as compared to a CHOP-based regimen. This is a multicentre study comprising 325 adult patients, median age 58 years, with high-grade non-Hodgkin's lymphoma: patients of any age and performance status were eligible provided they were able to receive the drugs in the regimens. Patients were randomised to either B-CHOP-M (bleomycin, cyclophosphamide, doxorubicin, vincristine, prednisolone and methotrexate) or PEEC-M (methylprednisolone, vindesine, etoposide, chlorambucil and methotrexate) alternating with B-CHOP-M. At a median follow-up of 9 years, there was no significant difference in overall survival or disease-free survival between the two arms. Toxicities for the two regimens were equivalent. This study confirms that for relatively unselected patients with high-grade non-Hodgkin's lymphoma, an alternating multidrug regimen does not improve upon the results obtained with B-CHOP-M.
Original languageEnglish
Pages (from-to)1195-201
Number of pages7
JournalEuropean journal of cancer (Oxford, England : 1990)
Volume33
Issue number8
Publication statusPublished - Jul 1997

Keywords

  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols
  • Bleomycin
  • Chlorambucil
  • Cyclophosphamide
  • Disease-Free Survival
  • Doxorubicin
  • Drug Administration Schedule
  • Etoposide
  • Follow-Up Studies
  • Humans
  • Lymphoma, Non-Hodgkin
  • Methotrexate
  • Methylprednisolone
  • Middle Aged
  • Prednisolone
  • Survival Rate
  • Vincristine
  • Vindesine

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