Projects per year
Abstract
Chromatin is not randomly organized in the nucleus, and its spatial organization participates in the regulation of genome functions. However, this spatial organization is also not entirely fixed and modifications of chromatin architecture are implicated in physiological processes such as differentiation or senescence. One of the most striking features of chromatin architecture is the concentration of heterochromatin at the nuclear periphery. A closer examination of the association of chromatin at the nuclear periphery reveals that heterochromatin accumulates at the nuclear lamina, whereas nuclear pores are usually devoid of heterochromatin. After summarizing the current techniques used to study the attachment of chromatin at the nuclear lamina or the nuclear pores, we review the mechanisms underlying these attachments, their plasticity and their consequences on the regulation of gene expression, DNA repair and replication.
| Original language | English |
|---|---|
| Pages (from-to) | 111-22 |
| Number of pages | 12 |
| Journal | Histochemistry and cell biology |
| Volume | 144 |
| Issue number | 2 |
| Early online date | 14 Jul 2015 |
| DOIs | |
| Publication status | Published - Aug 2015 |
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Dive into the research topics of 'Chromatin at the nuclear periphery and the regulation of genome functions'. Together they form a unique fingerprint.Projects
- 3 Finished
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CROATIA PROGRAMME
Wright, A. (Principal Investigator), Adams, I. (Co-investigator), Aligianis, I. (Co-investigator), Baldock, R. (Co-investigator), Bickmore, W. (Co-investigator), Caceres, J. (Co-investigator), Dorin, J. (Co-investigator), Dunlop, M. (Co-investigator), FitzPatrick, D. (Co-investigator), Haley, C. (Co-investigator), Hastie, N. (Co-investigator), Hill, B. (Co-investigator), Jackson, I. (Co-investigator), Jackson, A. (Co-investigator), Kudla, G. (Co-investigator), Meehan, R. (Co-investigator), O'Connell, M. (Co-investigator), Overton, I. (Co-investigator), Patton, E. (Co-investigator), Taylor, M. (Co-investigator), Tenesa, A. (Co-investigator) & Van Heyningen, V. (Co-investigator)
1/04/12 → 31/07/13
Project: Research
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The role of spatial nuclear organisation in genome function
Bickmore, W. (Principal Investigator)
1/04/12 → 31/03/18
Project: Research
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FunctionalEdge: Determining the roles of the nuclear peri
Bickmore, W. (Principal Investigator)
1/10/11 → 28/02/16
Project: Research