Chromosomal position effects and the modulation of transgene expression

A J Clark, P Bissinger, D W Bullock, S Damak, R Wallace, C B Whitelaw, F Yull

Research output: Contribution to journalArticlepeer-review


Chromosomal position effects can influence strongly the transcription of foreign genes in transgenic animals. This results in low frequencies and levels of gene expression and, in some cases, in aberrant patterns of expression. Strategies for overcoming these effects are described with particular reference to their application in embryonic stem cells.
Original languageEnglish
Pages (from-to)589-98
Number of pages10
JournalReproduction, Fertility and Development
Issue number5
Publication statusPublished - 1994


  • Animals
  • Chromosomes
  • DNA, Recombinant
  • Embryo, Mammalian
  • Gene Expression
  • Gene Targeting
  • Gene Transfer Techniques
  • Humans
  • Stem Cells

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