Projects per year
Abstract
Studies on budding yeast have exposed the highly conserved mechanisms by which duplicated chromosomes are evenly distributed to daughter cells at the metaphase-anaphase transition. The establishment of proteinaceous bridges between sister chromatids, a function provided by a ring-shaped complex known as cohesin, is central to accurate segregation. It is the destruction of this cohesin that triggers the segregation of chromosomes following their proper attachment to microtubules. Since it is irreversible, this process must be tightly controlled and driven to completion. Furthermore, during meiosis, modifications must be put in place to allow the segregation of maternal and paternal chromosomes in the first division for gamete formation. Here, I review the pioneering work from budding yeast that has led to a molecular understanding of the establishment and destruction of cohesion.
Original language | English |
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Pages (from-to) | 31-63 |
Number of pages | 33 |
Journal | Genetics |
Volume | 196 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2014 |
Keywords / Materials (for Non-textual outputs)
- Keyords placeholder
- Mitosis
- Meiosis
- Chromosome
- Cohesin,
- Segregation
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Dive into the research topics of 'Chromosome segregation in budding yeast: sister chromatid cohesion and related mechanisms'. Together they form a unique fingerprint.Projects
- 2 Finished
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How are centrosomes/SPBs licensed at the meiosis I to meiosis II transition?
1/03/13 → 28/02/16
Project: Research
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The role of the Pericentromere in Mitosis and Meiosis (linked to R42666)
28/02/11 → 27/02/16
Project: Research