Chronic amitriptyline treatment induces hippocampal NGFI-A, glucocorticoid receptor and mineralocorticoid receptor mRNA expression in rats

I M  Johansson; L  Bjartmar; J  Marcusson; S B  Ross; J R  Seckl; T  Olsson

Chronic amitriptyline treatment induces hippocampal NGFI-A, glucocorticoid receptor and mineralocorticoid receptor mRNA expression in rats

I M Johansson
, L Bjartmar
, J Marcusson
, S B Ross
, J R Seckl
, T Olsson

School of Regeneration and Repair

Research output: Contribution to journal › Article › peer-review

Abstract

Adult male rats were treated with the antidepressant drug amitriptyline for 21 days and the expression of specific transcription factors was examined. NGFI-A mRNA expression was increased in the hippocampus and in the cerebral cortex. MR mRNA was increased in the hippocampus while GR mRNA was increased in selective hippocampal regions, There was no change in the NGFI-B mRNA expression. Thus, NCFI-A may be a mediator of plasticity-related phenomena induced by antidepressant drugs. (C) 1998 Elsevier Science B.V. All rights reserved.

Original language	English
Pages (from-to)	92-95
Number of pages	4
Journal	Molecular brain research
Volume	62
Issue number	1
Publication status	Published - 12 Nov 1998

Cite this

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title = "Chronic amitriptyline treatment induces hippocampal NGFI-A, glucocorticoid receptor and mineralocorticoid receptor mRNA expression in rats",

abstract = "Adult male rats were treated with the antidepressant drug amitriptyline for 21 days and the expression of specific transcription factors was examined. NGFI-A mRNA expression was increased in the hippocampus and in the cerebral cortex. MR mRNA was increased in the hippocampus while GR mRNA was increased in selective hippocampal regions, There was no change in the NGFI-B mRNA expression. Thus, NCFI-A may be a mediator of plasticity-related phenomena induced by antidepressant drugs. (C) 1998 Elsevier Science B.V. All rights reserved.",

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T1 - Chronic amitriptyline treatment induces hippocampal NGFI-A, glucocorticoid receptor and mineralocorticoid receptor mRNA expression in rats

AU - Johansson, I M

AU - Bjartmar, L

AU - Marcusson, J

AU - Ross, S B

AU - Seckl, J R

AU - Olsson, T

PY - 1998/11/12

Y1 - 1998/11/12

N2 - Adult male rats were treated with the antidepressant drug amitriptyline for 21 days and the expression of specific transcription factors was examined. NGFI-A mRNA expression was increased in the hippocampus and in the cerebral cortex. MR mRNA was increased in the hippocampus while GR mRNA was increased in selective hippocampal regions, There was no change in the NGFI-B mRNA expression. Thus, NCFI-A may be a mediator of plasticity-related phenomena induced by antidepressant drugs. (C) 1998 Elsevier Science B.V. All rights reserved.

AB - Adult male rats were treated with the antidepressant drug amitriptyline for 21 days and the expression of specific transcription factors was examined. NGFI-A mRNA expression was increased in the hippocampus and in the cerebral cortex. MR mRNA was increased in the hippocampus while GR mRNA was increased in selective hippocampal regions, There was no change in the NGFI-B mRNA expression. Thus, NCFI-A may be a mediator of plasticity-related phenomena induced by antidepressant drugs. (C) 1998 Elsevier Science B.V. All rights reserved.

M3 - Article

SN - 0169-328X

VL - 62

SP - 92

EP - 95

JO - Molecular brain research

JF - Molecular brain research

IS - 1

ER -

Chronic amitriptyline treatment induces hippocampal NGFI-A, glucocorticoid receptor and mineralocorticoid receptor mRNA expression in rats

Abstract

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