Chronic kidney disease after liver transplantation for acute liver failure is not associated with perioperative renal dysfunction

J A Leithead, J W Ferguson, C M Bates, J S Davidson, Kenneth Simpson, P C Hayes

Research output: Contribution to journalArticlepeer-review

Abstract

Renal dysfunction of acute liver failure (ALF) may have distinct pathophysiological mechanisms to hepatorenal syndrome of cirrhosis. Yet, the impact of perioperative renal function on posttransplant renal outcomes in ALF patients specifically has not been established. The aims of this study were (1) to describe the incidence and risk factors for chronic renal dysfunction following liver transplantation for ALF and (2) to compare renal outcomes with age-sex-matched patients transplanted for chronic liver disease. This was a single-center study of 101 patients transplanted for ALF. Fifty-three-and-a-half percent had pretransplant acute kidney injury and 64.9% required perioperative renal replacement therapy. After transplantation the 5-year cumulative incidence of chronic kidney disease (eGFR
Original languageEnglish
Pages (from-to)1905-15
Number of pages11
JournalAmerican Journal of Transplantation
Volume11
Issue number9
DOIs
Publication statusPublished - 2011

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