Chronic oligodendrocyte injury in central nervous system pathologies

Irene Molina-Gonzalez, Véronique E Miron, Jack P. Antel

Research output: Contribution to journalArticlepeer-review


Myelin, the membrane surrounding neuronal axons, is critical for central nervous system (CNS) function. Injury to myelin-forming oligodendrocytes (OL) in chronic neurological diseases (e.g. multiple sclerosis) ranges from sublethal to lethal, leading to OL dysfunction and myelin pathology, and consequent deleterious impacts on axonal health that drive clinical impairments. This is regulated by intrinsic factors such as heterogeneity and age, and extrinsic cellular and molecular interactions. Here, we discuss the responses of OLs to injury, and perspectives for therapeutic targeting. We put forward that targeting mature OL health in neurological disease is a promising therapeutic strategy to support CNS function.
Original languageEnglish
Article number1274
Number of pages11
JournalCommunications biology
Publication statusPublished - 19 Nov 2022


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