Chronic osteomyelitis. The effect of the extent of surgical resection on infection-free survival

A H Simpson, M Deakin, J M Latham

Research output: Contribution to journalArticlepeer-review

Abstract

We studied prospectively a consecutive series of 50 patients with chronic osteomyelitis. Patients were allocated to the following treatment groups: 1) wide resection, with a clearance margin of 5 mm or more; 2) marginal resection, with a clearance margin of less than 5 mm; and 3) intralesional biopsy, with debulking of the infected area. All patients had a course of antibiotics, intravenously for six weeks followed by orally for a further six weeks. No patients in group 1 had recurrence. In patients treated by marginal resection (group 2), 8 of 29 (28%) had recurrence. All patients who had debulking had a recurrence within one year of surgery. We performed a survival analysis to determine the time of the recurrence of infection. In group 2 there was a higher rate of recurrence in type-B hosts (p < 0.05); no type-A hosts had recurrence. This information is of use in planning surgery for chronic osteomyelitis.

Original languageEnglish
Pages (from-to)403-7
Number of pages5
JournalJournal of Bone and Joint Surgery, British Volume
Volume83
Issue number3
Publication statusPublished - Apr 2001

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents
  • Chronic Disease
  • Female
  • Humans
  • Male
  • Middle Aged
  • Orthopedic Procedures
  • Osteomyelitis
  • Prospective Studies
  • Recurrence

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