Circulating apoptotic and necrotic cell death markers in patients with acute liver injury

Darren G N Craig; Patricia Lee; Elizabeth A Pryde; Gail S Masterton; Peter C Hayes; Kenneth J Simpson

doi:10.1111/j.1478-3231.2011.02528.x

Circulating apoptotic and necrotic cell death markers in patients with acute liver injury

Darren G N Craig, Patricia Lee, Elizabeth A Pryde, Gail S Masterton, Peter C Hayes, Kenneth J Simpson

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

The host response to cell death underpins the immune activation that follows acute liver injury, and measurement of circulating cell death markers could therefore aid prognostication following paracetamol overdose. Nucleosomes, formed during apoptosis, can complex with high-mobility group box 1 (HMGB1) protein and may play a pathogenic role in liver injury.

Original language	English
Pages (from-to)	1127-36
Number of pages	10
Journal	Liver International
Volume	31
Issue number	8
DOIs	https://doi.org/10.1111/j.1478-3231.2011.02528.x
Publication status	Published - 2011

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title = "Circulating apoptotic and necrotic cell death markers in patients with acute liver injury",

abstract = "The host response to cell death underpins the immune activation that follows acute liver injury, and measurement of circulating cell death markers could therefore aid prognostication following paracetamol overdose. Nucleosomes, formed during apoptosis, can complex with high-mobility group box 1 (HMGB1) protein and may play a pathogenic role in liver injury.",

author = "Craig, {Darren G N} and Patricia Lee and Pryde, {Elizabeth A} and Masterton, {Gail S} and Hayes, {Peter C} and Simpson, {Kenneth J}",

note = "{\textcopyright} 2011 John Wiley & Sons A/S.",

year = "2011",

doi = "10.1111/j.1478-3231.2011.02528.x",

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T1 - Circulating apoptotic and necrotic cell death markers in patients with acute liver injury

AU - Craig, Darren G N

AU - Lee, Patricia

AU - Pryde, Elizabeth A

AU - Masterton, Gail S

AU - Hayes, Peter C

AU - Simpson, Kenneth J

PY - 2011

Y1 - 2011

N2 - The host response to cell death underpins the immune activation that follows acute liver injury, and measurement of circulating cell death markers could therefore aid prognostication following paracetamol overdose. Nucleosomes, formed during apoptosis, can complex with high-mobility group box 1 (HMGB1) protein and may play a pathogenic role in liver injury.

AB - The host response to cell death underpins the immune activation that follows acute liver injury, and measurement of circulating cell death markers could therefore aid prognostication following paracetamol overdose. Nucleosomes, formed during apoptosis, can complex with high-mobility group box 1 (HMGB1) protein and may play a pathogenic role in liver injury.

UR - http://www.scopus.com/inward/record.url?scp=79961209077&partnerID=8YFLogxK

U2 - 10.1111/j.1478-3231.2011.02528.x

DO - 10.1111/j.1478-3231.2011.02528.x

M3 - Article

C2 - 21745283

SN - 1478-3231

VL - 31

SP - 1127

EP - 1136

JO - Liver International

JF - Liver International

IS - 8

ER -

Circulating apoptotic and necrotic cell death markers in patients with acute liver injury

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