Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD

Roberto Rabinovich, Bruce E Miller, Karolina Wrobel, Kareshma Ranjit, Michelle Williams, Ellen Drost, Lisa D Edwards, David A Lomas, Stephen I Rennard, Alvar Agusti, Ruth Tal-Singer, Jørgen Vestbo, Emiel F. M. Wouters, Michelle John, Edwin van Beek, John T Murchison, Charlotte E Bolton, William MacNee, Jeffrey T J Huang

Research output: Contribution to journalArticlepeer-review

Abstract

Elastin degradation is a key feature of emphysema and may have a role in the pathogenesis of atherosclerosis associated with COPD. Circulating desmosine is a specific biomarker of elastin degradation. We investigated the association between plasma desmosine (pDES) and emphysema severity/progression, coronary artery calcium score (CACS) and mortality. pDES was measured in 1,177 COPD patients and 110 healthy control subjects from two independent cohorts. Emphysema was assessed on chest CT scans. Aortic arterial stiffness was measured as the aortic–femoral pulse wave velocity. pDES was elevated in patients with cardiovascular disease (CVD) (p<0.005) and correlated with age (rho=0.39, p<0.0005), CACS (rho=0.19, p<0.0005) mMRC (rho=0.15, p<0.0005), 6MWD (rho=-0.17, p<0.0005) and BODE index (rho=0.10, p<0.01), but not with emphysema, emphysema progression or FEV1 decline. pDES predicted all-cause mortality independently of several confounding factors (p<0.005). In an independent cohort of 186 patients with COPD and 110 control subjects, pDES levels were higher in COPD patients with CVD and correlated with arterial stiffness (p<0.05). In COPD, excess elastin degradation relates to cardiovascular comorbidities, atherosclerosis, arterial stiffness systemic inflammation and mortality, but not to emphysema or emphysema progression. pDES is a good biomarker of cardiovascular risk and mortality in COPD.
Original languageEnglish
JournalEuropean Respiratory Journal
DOIs
Publication statusPublished - 1 May 2016

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