Circulating Inflammatory Markers Are Associated With Magnetic Resonance Imaging-Visible Perivascular Spaces But Not Directly With White Matter Hyperintensities

Benjamin S Aribisala; Stewart Wiseman; Zoe Morris; Maria Valdes Hernandez; Natalie A Royle; Susana Munoz-Maniega; Alan J Gow; Janie Corley; Mark E Bastin; John Starr; Ian J Deary; Joanna M Wardlaw

doi:10.1161/STROKEAHA.113.004059

Circulating Inflammatory Markers Are Associated With Magnetic Resonance Imaging-Visible Perivascular Spaces But Not Directly With White Matter Hyperintensities

Benjamin S Aribisala, Stewart Wiseman, Zoe Morris, Maria Valdes Hernandez, Natalie A Royle, Susana Munoz-Maniega, Alan J Gow, Janie Corley, Mark E Bastin, John Starr, Ian J Deary, Joanna M Wardlaw

Research output: Contribution to journal › Article › peer-review

Abstract

White matter hyperintensities (WMH) and perivascular spaces (PVS) are features of small vessel disease, found jointly on MRI of older people. Inflammation is a prominent pathological feature of small vessel disease. We examined the association between inflammation, PVS, and WMH in the Lothian Birth Cohort 1936 (N=634).

Original language	English
Pages (from-to)	605-607
Number of pages	3
Journal	Stroke
Volume	45
Issue number	2
Early online date	7 Jan 2014
DOIs	https://doi.org/10.1161/STROKEAHA.113.004059
Publication status	Published - 7 Jan 2014

Keywords / Materials (for Non-textual outputs)

inflammatory markers
MRI
perivascular spaces
White matter hyperintensities
aging
leukoaraiosis
Leukoencephalopathies

Access to Document

10.1161/STROKEAHA.113.004059

Inflammation PVS WMH manuscript revision R3 27 11 2013
© Aribisala, B. S., Wiseman, S., Morris, Z., Valdés-Hernández, M. C., Royle, N. A., Maniega, S. M., ... Wardlaw, J. M. (2014). Circulating Inflammatory Markers Are Associated With Magnetic Resonance Imaging-Visible Perivascular Spaces But Not Directly With White Matter Hyperintensities. Stroke, 45(2), 605-607. 10.1161/STROKEAHA.113.004059
Accepted author manuscript, 35.2 KB
Figure 1
© Aribisala, B. S., Wiseman, S., Morris, Z., Valdés-Hernández, M. C., Royle, N. A., Maniega, S. M., ... Wardlaw, J. M. (2014). Circulating Inflammatory Markers Are Associated With Magnetic Resonance Imaging-Visible Perivascular Spaces But Not Directly With White Matter Hyperintensities. Stroke, 45(2), 605-607. 10.1161/STROKEAHA.113.004059
Accepted author manuscript, 72.4 KB
Figure 2
© Aribisala, B. S., Wiseman, S., Morris, Z., Valdés-Hernández, M. C., Royle, N. A., Maniega, S. M., ... Wardlaw, J. M. (2014). Circulating Inflammatory Markers Are Associated With Magnetic Resonance Imaging-Visible Perivascular Spaces But Not Directly With White Matter Hyperintensities. Stroke, 45(2), 605-607. 10.1161/STROKEAHA.113.004059
Accepted author manuscript, 59.6 KB
Figure 3
© Aribisala, B. S., Wiseman, S., Morris, Z., Valdés-Hernández, M. C., Royle, N. A., Maniega, S. M., ... Wardlaw, J. M. (2014). Circulating Inflammatory Markers Are Associated With Magnetic Resonance Imaging-Visible Perivascular Spaces But Not Directly With White Matter Hyperintensities. Stroke, 45(2), 605-607. 10.1161/STROKEAHA.113.004059
Accepted author manuscript, 86.9 KB
Supplementary materials
© Aribisala, B. S., Wiseman, S., Morris, Z., Valdés-Hernández, M. C., Royle, N. A., Maniega, S. M., ... Wardlaw, J. M. (2014). Circulating Inflammatory Markers Are Associated With Magnetic Resonance Imaging-Visible Perivascular Spaces But Not Directly With White Matter Hyperintensities. Stroke, 45(2), 605-607. 10.1161/STROKEAHA.113.004059
Accepted author manuscript, 262 KB

Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.
Maclullich, A. (Principal Investigator)
1/09/13 → 31/08/19
Project: Research
RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.
Deary, I. (Principal Investigator), Gale, C. (Co-investigator), Holmes, M. (Co-investigator), Logie, P. (Co-investigator), Maclullich, A. (Co-investigator), Porteous, D. (Co-investigator), Seckl, J. (Co-investigator), Starr, J. (Co-investigator), Wardlaw, J. (Co-investigator) & Okely, J. (Researcher)
1/09/13 → 31/08/19
Project: Research
Brain White mater imaging and cognitive ageing in the Lothian Birth Cohort of 1936:II
Deary, I. (Principal Investigator), Bastin, M. (Co-investigator), Penke, L. (Co-investigator), Starr, J. (Co-investigator) & Wardlaw, J. (Co-investigator)
MRC
8/06/11 → 7/03/15
Project: Research

Cite this

Aribisala, B. S., Wiseman, S., Morris, Z., Valdes Hernandez, M., Royle, N. A., Munoz-Maniega, S., Gow, A. J., Corley, J., Bastin, M. E., Starr, J., Deary, I. J., & Wardlaw, J. M. (2014). Circulating Inflammatory Markers Are Associated With Magnetic Resonance Imaging-Visible Perivascular Spaces But Not Directly With White Matter Hyperintensities. Stroke, 45(2), 605-607. https://doi.org/10.1161/STROKEAHA.113.004059

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abstract = "White matter hyperintensities (WMH) and perivascular spaces (PVS) are features of small vessel disease, found jointly on MRI of older people. Inflammation is a prominent pathological feature of small vessel disease. We examined the association between inflammation, PVS, and WMH in the Lothian Birth Cohort 1936 (N=634).",

keywords = "inflammatory markers, MRI, perivascular spaces, White matter hyperintensities, aging, leukoaraiosis , Leukoencephalopathies",

author = "Aribisala, {Benjamin S} and Stewart Wiseman and Zoe Morris and {Valdes Hernandez}, Maria and Royle, {Natalie A} and Susana Munoz-Maniega and Gow, {Alan J} and Janie Corley and Bastin, {Mark E} and John Starr and Deary, {Ian J} and Wardlaw, {Joanna M}",

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doi = "10.1161/STROKEAHA.113.004059",

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Aribisala, BS, Wiseman, S, Morris, Z, Valdes Hernandez, M, Royle, NA, Munoz-Maniega, S, Gow, AJ, Corley, J , Bastin, ME, Starr, J, Deary, IJ & Wardlaw, JM 2014, 'Circulating Inflammatory Markers Are Associated With Magnetic Resonance Imaging-Visible Perivascular Spaces But Not Directly With White Matter Hyperintensities', Stroke, vol. 45, no. 2, pp. 605-607. https://doi.org/10.1161/STROKEAHA.113.004059

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T1 - Circulating Inflammatory Markers Are Associated With Magnetic Resonance Imaging-Visible Perivascular Spaces But Not Directly With White Matter Hyperintensities

AU - Aribisala, Benjamin S

AU - Wiseman, Stewart

AU - Morris, Zoe

AU - Valdes Hernandez, Maria

AU - Royle, Natalie A

AU - Munoz-Maniega, Susana

AU - Gow, Alan J

AU - Corley, Janie

AU - Bastin, Mark E

AU - Starr, John

AU - Deary, Ian J

AU - Wardlaw, Joanna M

PY - 2014/1/7

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AB - White matter hyperintensities (WMH) and perivascular spaces (PVS) are features of small vessel disease, found jointly on MRI of older people. Inflammation is a prominent pathological feature of small vessel disease. We examined the association between inflammation, PVS, and WMH in the Lothian Birth Cohort 1936 (N=634).

KW - inflammatory markers

KW - MRI

KW - perivascular spaces

KW - White matter hyperintensities

KW - aging

KW - leukoaraiosis

KW - Leukoencephalopathies

U2 - 10.1161/STROKEAHA.113.004059

DO - 10.1161/STROKEAHA.113.004059

M3 - Article

C2 - 24399375

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JO - Stroke

JF - Stroke

IS - 2

ER -

Circulating Inflammatory Markers Are Associated With Magnetic Resonance Imaging-Visible Perivascular Spaces But Not Directly With White Matter Hyperintensities

Abstract

Keywords / Materials (for Non-textual outputs)

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Projects

Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.

RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.

Brain White mater imaging and cognitive ageing in the Lothian Birth Cohort of 1936:II

Cite this