Circulating Inflammatory Markers Are Associated With Magnetic Resonance Imaging-Visible Perivascular Spaces But Not Directly With White Matter Hyperintensities

Benjamin S Aribisala, Stewart Wiseman, Zoe Morris, Maria Valdes Hernandez, Natalie A Royle, Susana Munoz-Maniega, Alan J Gow, Janie Corley, Mark E Bastin, John Starr, Ian J Deary, Joanna M Wardlaw

Research output: Contribution to journalArticlepeer-review

Abstract

White matter hyperintensities (WMH) and perivascular spaces (PVS) are features of small vessel disease, found jointly on MRI of older people. Inflammation is a prominent pathological feature of small vessel disease. We examined the association between inflammation, PVS, and WMH in the Lothian Birth Cohort 1936 (N=634).
Original languageEnglish
Pages (from-to)605-607
Number of pages3
JournalStroke
Volume45
Issue number2
Early online date7 Jan 2014
DOIs
Publication statusPublished - 7 Jan 2014

Keywords

  • inflammatory markers
  • MRI
  • perivascular spaces
  • White matter hyperintensities
  • aging
  • leukoaraiosis
  • Leukoencephalopathies

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