Clinical course and risk factors for mortality of COVID-19 patients with pre-existing cirrhosis: a multicentre cohort study

Xiaolong Qi; Yanna Liu; Jitao Wang; Jonathan Fallowfield; Jianwen Wang; Xinyu Li; Jindong Shi; Hongqiu Pan; Shengqiang Zou; Hongguang Zhang; Zhenhuai Chen; Fujian Li; Yan Luo; Mei Mei; Huiling Liu; Zhengyan Wang; Jinlin Li; Hua Yang; Huihua Xiang; Xiaodan Li; Tao Liu; Ming-hua Zheng; Chuan Liu; Yifei Huang; Dan Xu; Xiaoguo Li; Ning Kang; Qing He; Ye Gu; Guo Zhang; Chuxiao Shao; Dengxiang Liu; Lin Zhang; Xun Li; Norifumi Kawada; Zicheng Jiang; Fengmei Wang; Bin Xiong; Tetsuo Takehara; Don C Rockey

doi:10.1136/gutjnl-2020-321666

Clinical course and risk factors for mortality of COVID-19 patients with pre-existing cirrhosis: a multicentre cohort study

Xiaolong Qi, Yanna Liu, Jitao Wang, Jonathan Fallowfield, Jianwen Wang, Xinyu Li, Jindong Shi, Hongqiu Pan, Shengqiang Zou, Hongguang Zhang, Zhenhuai Chen, Fujian Li, Yan Luo, Mei Mei, Huiling Liu, Zhengyan Wang, Jinlin Li, Hua Yang, Huihua Xiang, Xiaodan LiTao Liu, Ming-hua Zheng, Chuan Liu, Yifei Huang, Dan Xu, Xiaoguo Li, Ning Kang, Qing He, Ye Gu, Guo Zhang, Chuxiao Shao, Dengxiang Liu, Lin Zhang, Xun Li, Norifumi Kawada, Zicheng Jiang, Fengmei Wang, Bin Xiong, Tetsuo Takehara, Don C Rockey

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Abstract / Description of output

In this study we provide the first report of the characteristics, comorbidities,
laboratory and x-ray findings, and clinical outcomes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients with pre-existing liver cirrhosis. The cause of death in most patients was respiratory failure rather than progression of liver disease. Lower numbers of blood lymphocytes and platelets, and higher bilirubin levels might represent indicators of poor outcome in this patient population.

Original language	English
Pages (from-to)	gutjnl-2020-321666
Journal	Gut
Early online date	20 May 2020
DOIs	https://doi.org/10.1136/gutjnl-2020-321666
Publication status	E-pub ahead of print - 20 May 2020

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10.1136/gutjnl-2020-321666

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Author's peer reviewed manuscript as accepted for publication.
Accepted author manuscript, 49.6 KBLicence: Creative Commons: Attribution Non-Commercial (CC-BY-NC)

http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2020-321666

Jonathan Fallowfield
- Jonathan.Fallowfielded.acuk
- Deanery of Clinical Sciences - Personal Chair of Translational Liver Research
- Centre for Inflammation Research
- Edinburgh Imaging
Person: Academic: Research Active (Research Assistant)

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Qi, X., Liu, Y., Wang, J., Fallowfield, J., Wang, J., Li, X., Shi, J., Pan, H., Zou, S., Zhang, H., Chen, Z., Li, F., Luo, Y., Mei, M., Liu, H., Wang, Z., Li, J., Yang, H., Xiang, H., ... Rockey, D. C. (2020). Clinical course and risk factors for mortality of COVID-19 patients with pre-existing cirrhosis: a multicentre cohort study. Gut, gutjnl-2020-321666. Advance online publication. https://doi.org/10.1136/gutjnl-2020-321666

@article{198d3ffd509242c1ba274757f2325151,

title = "Clinical course and risk factors for mortality of COVID-19 patients with pre-existing cirrhosis: a multicentre cohort study",

abstract = "In this study we provide the first report of the characteristics, comorbidities,laboratory and x-ray findings, and clinical outcomes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients with pre-existing liver cirrhosis. The cause of death in most patients was respiratory failure rather than progression of liver disease. Lower numbers of blood lymphocytes and platelets, and higher bilirubin levels might represent indicators of poor outcome in this patient population.",

author = "Xiaolong Qi and Yanna Liu and Jitao Wang and Jonathan Fallowfield and Jianwen Wang and Xinyu Li and Jindong Shi and Hongqiu Pan and Shengqiang Zou and Hongguang Zhang and Zhenhuai Chen and Fujian Li and Yan Luo and Mei Mei and Huiling Liu and Zhengyan Wang and Jinlin Li and Hua Yang and Huihua Xiang and Xiaodan Li and Tao Liu and Ming-hua Zheng and Chuan Liu and Yifei Huang and Dan Xu and Xiaoguo Li and Ning Kang and Qing He and Ye Gu and Guo Zhang and Chuxiao Shao and Dengxiang Liu and Lin Zhang and Xun Li and Norifumi Kawada and Zicheng Jiang and Fengmei Wang and Bin Xiong and Tetsuo Takehara and Rockey, {Don C}",

year = "2020",

month = may,

day = "20",

doi = "10.1136/gutjnl-2020-321666",

language = "English",

pages = "gutjnl--2020--321666",

journal = "Gut",

issn = "0017-5749",

publisher = "BMJ Publishing Group",

}

Qi, X, Liu, Y, Wang, J, Fallowfield, J, Wang, J, Li, X, Shi, J, Pan, H, Zou, S, Zhang, H, Chen, Z, Li, F, Luo, Y, Mei, M, Liu, H, Wang, Z, Li, J, Yang, H, Xiang, H, Li, X, Liu, T, Zheng, M, Liu, C, Huang, Y, Xu, D, Li, X, Kang, N, He, Q, Gu, Y, Zhang, G, Shao, C, Liu, D, Zhang, L, Li, X, Kawada, N, Jiang, Z, Wang, F, Xiong, B, Takehara, T & Rockey, DC 2020, 'Clinical course and risk factors for mortality of COVID-19 patients with pre-existing cirrhosis: a multicentre cohort study', Gut, pp. gutjnl-2020-321666. https://doi.org/10.1136/gutjnl-2020-321666

TY - JOUR

T1 - Clinical course and risk factors for mortality of COVID-19 patients with pre-existing cirrhosis: a multicentre cohort study

AU - Qi, Xiaolong

AU - Liu, Yanna

AU - Wang, Jitao

AU - Fallowfield, Jonathan

AU - Wang, Jianwen

AU - Li, Xinyu

AU - Shi, Jindong

AU - Pan, Hongqiu

AU - Zou, Shengqiang

AU - Zhang, Hongguang

AU - Chen, Zhenhuai

AU - Li, Fujian

AU - Luo, Yan

AU - Mei, Mei

AU - Liu, Huiling

AU - Wang, Zhengyan

AU - Li, Jinlin

AU - Yang, Hua

AU - Xiang, Huihua

AU - Li, Xiaodan

AU - Liu, Tao

AU - Zheng, Ming-hua

AU - Liu, Chuan

AU - Huang, Yifei

AU - Xu, Dan

AU - Li, Xiaoguo

AU - Kang, Ning

AU - He, Qing

AU - Gu, Ye

AU - Zhang, Guo

AU - Shao, Chuxiao

AU - Liu, Dengxiang

AU - Zhang, Lin

AU - Li, Xun

AU - Kawada, Norifumi

AU - Jiang, Zicheng

AU - Wang, Fengmei

AU - Xiong, Bin

AU - Takehara, Tetsuo

AU - Rockey, Don C

PY - 2020/5/20

Y1 - 2020/5/20

N2 - In this study we provide the first report of the characteristics, comorbidities,laboratory and x-ray findings, and clinical outcomes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients with pre-existing liver cirrhosis. The cause of death in most patients was respiratory failure rather than progression of liver disease. Lower numbers of blood lymphocytes and platelets, and higher bilirubin levels might represent indicators of poor outcome in this patient population.

AB - In this study we provide the first report of the characteristics, comorbidities,laboratory and x-ray findings, and clinical outcomes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients with pre-existing liver cirrhosis. The cause of death in most patients was respiratory failure rather than progression of liver disease. Lower numbers of blood lymphocytes and platelets, and higher bilirubin levels might represent indicators of poor outcome in this patient population.

U2 - 10.1136/gutjnl-2020-321666

DO - 10.1136/gutjnl-2020-321666

M3 - Letter

SN - 0017-5749

SP - gutjnl-2020-321666

JO - Gut

JF - Gut

ER -

Clinical course and risk factors for mortality of COVID-19 patients with pre-existing cirrhosis: a multicentre cohort study

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Jonathan Fallowfield

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