Clinical effects of a constant rate infusion of remifentanil, alone or in combination with ketamine, in cats anesthetized with isoflurane

Paulo V M Steagall; Monica Aucoin; Beatriz P Monteiro; Maxim Moreau; Brad T Simon; Patrick M Burns

doi:10.2460/javma.246.9.976

Clinical effects of a constant rate infusion of remifentanil, alone or in combination with ketamine, in cats anesthetized with isoflurane

Paulo V M Steagall, Monica Aucoin, Beatriz P Monteiro, Maxim Moreau, Brad T Simon, Patrick M Burns

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

OBJECTIVE: To evaluate the effects of a constant rate infusion of remifentanil, alone or in combination with ketamine, in healthy cats anesthetized with isoflurane.

DESIGN: Randomized, controlled, clinical trial.

ANIMALS: 23 cats undergoing elective ovariohysterectomy.

PROCEDURES: Cats were premedicated with acepromazine and morphine; anesthesia was induced with propofol and maintained with isoflurane. Cats were given constant rate infusions of remifentanil (20 μg/kg/h [9 μg/lb/h], IV; n = 8), remifentanil and ketamine (0.5 mg/kg [0.23 mg/lb], then 1.8 mg/kg/h [0.82 mg/lb/h], IV; 7), or crystalloid fluids (8). The anesthesiologist was blinded to treatment group, end-tidal isoflurane concentration, and vaporizer setting. Heart rate, systolic arterial blood pressure, respiratory rate, end-tidal partial pressure of CO2, temperature, and end-tidal isoflurane concentration were monitored; recovery scores were assigned.

RESULTS: There were no significant differences among treatment groups with respect to age, body weight, surgery time, anesthesia time, time to extubation, recovery score, or cardiorespiratory variables. End-tidal isoflurane concentration was significantly reduced in cats given remifentanil and ketamine (mean ± SD, 0.63 ± 0.4%), compared with concentration in cats given crystalloid fluids (1.22 ± 0.5%) but not compared with concentration in cats given remifentanil alone (1.03 ± 0.4%). Compared with cats given crystalloid fluids, mean isoflurane requirement was reduced by 48.3% in cats given remifentanil-ketamine and 15.6% in cats given remifentanil alone.

CONCLUSIONS AND CLINICAL RELEVANCE: At the dosages administered, a constant rate infusion of remifentanil-ketamine resulted in a significant decrease in the isoflurane requirement in healthy cats undergoing ovariohysterectomy. However, significant differences in cardiovascular variables were not observed among treatment groups.

Original language	English
Pages (from-to)	976-81
Number of pages	6
Journal	Journal of the American Veterinary Medical Association
Volume	246
Issue number	9
DOIs	https://doi.org/10.2460/javma.246.9.976
Publication status	Published - 1 May 2015
Externally published	Yes

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10.2460/javma.246.9.976

Clinical effects of a constant rate infusion of remifentanil, alone or in combination with ketamine, in cats anesthetized with isoflurane
Steagall, P. V. M., Aucoin, M., Monteiro, B. P., Moreau, M., Simon, B. T. & Burns, P.
1/01/14 → 31/12/14
Project: Project from a former institution

Cite this

@article{80957941b904442c9c209fd20c3326a4,

title = "Clinical effects of a constant rate infusion of remifentanil, alone or in combination with ketamine, in cats anesthetized with isoflurane",

abstract = "OBJECTIVE: To evaluate the effects of a constant rate infusion of remifentanil, alone or in combination with ketamine, in healthy cats anesthetized with isoflurane.DESIGN: Randomized, controlled, clinical trial.ANIMALS: 23 cats undergoing elective ovariohysterectomy.PROCEDURES: Cats were premedicated with acepromazine and morphine; anesthesia was induced with propofol and maintained with isoflurane. Cats were given constant rate infusions of remifentanil (20 μg/kg/h [9 μg/lb/h], IV; n = 8), remifentanil and ketamine (0.5 mg/kg [0.23 mg/lb], then 1.8 mg/kg/h [0.82 mg/lb/h], IV; 7), or crystalloid fluids (8). The anesthesiologist was blinded to treatment group, end-tidal isoflurane concentration, and vaporizer setting. Heart rate, systolic arterial blood pressure, respiratory rate, end-tidal partial pressure of CO2, temperature, and end-tidal isoflurane concentration were monitored; recovery scores were assigned.RESULTS: There were no significant differences among treatment groups with respect to age, body weight, surgery time, anesthesia time, time to extubation, recovery score, or cardiorespiratory variables. End-tidal isoflurane concentration was significantly reduced in cats given remifentanil and ketamine (mean ± SD, 0.63 ± 0.4%), compared with concentration in cats given crystalloid fluids (1.22 ± 0.5%) but not compared with concentration in cats given remifentanil alone (1.03 ± 0.4%). Compared with cats given crystalloid fluids, mean isoflurane requirement was reduced by 48.3% in cats given remifentanil-ketamine and 15.6% in cats given remifentanil alone.CONCLUSIONS AND CLINICAL RELEVANCE: At the dosages administered, a constant rate infusion of remifentanil-ketamine resulted in a significant decrease in the isoflurane requirement in healthy cats undergoing ovariohysterectomy. However, significant differences in cardiovascular variables were not observed among treatment groups.",

author = "Steagall, {Paulo V M} and Monica Aucoin and Monteiro, {Beatriz P} and Maxim Moreau and Simon, {Brad T} and Burns, {Patrick M}",

year = "2015",

month = may,

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doi = "10.2460/javma.246.9.976",

language = "English",

volume = "246",

pages = "976--81",

journal = "Journal of the American Veterinary Medical Association",

issn = "0003-1488",

publisher = "American Veterinary Medical Association",

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Clinical effects of a constant rate infusion of remifentanil, alone or in combination with ketamine, in cats anesthetized with isoflurane. / Steagall, Paulo V M; Aucoin, Monica; Monteiro, Beatriz P et al.
In: Journal of the American Veterinary Medical Association, Vol. 246, No. 9, 01.05.2015, p. 976-81.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Clinical effects of a constant rate infusion of remifentanil, alone or in combination with ketamine, in cats anesthetized with isoflurane

AU - Steagall, Paulo V M

AU - Aucoin, Monica

AU - Monteiro, Beatriz P

AU - Moreau, Maxim

AU - Simon, Brad T

AU - Burns, Patrick M

PY - 2015/5/1

Y1 - 2015/5/1

N2 - OBJECTIVE: To evaluate the effects of a constant rate infusion of remifentanil, alone or in combination with ketamine, in healthy cats anesthetized with isoflurane.DESIGN: Randomized, controlled, clinical trial.ANIMALS: 23 cats undergoing elective ovariohysterectomy.PROCEDURES: Cats were premedicated with acepromazine and morphine; anesthesia was induced with propofol and maintained with isoflurane. Cats were given constant rate infusions of remifentanil (20 μg/kg/h [9 μg/lb/h], IV; n = 8), remifentanil and ketamine (0.5 mg/kg [0.23 mg/lb], then 1.8 mg/kg/h [0.82 mg/lb/h], IV; 7), or crystalloid fluids (8). The anesthesiologist was blinded to treatment group, end-tidal isoflurane concentration, and vaporizer setting. Heart rate, systolic arterial blood pressure, respiratory rate, end-tidal partial pressure of CO2, temperature, and end-tidal isoflurane concentration were monitored; recovery scores were assigned.RESULTS: There were no significant differences among treatment groups with respect to age, body weight, surgery time, anesthesia time, time to extubation, recovery score, or cardiorespiratory variables. End-tidal isoflurane concentration was significantly reduced in cats given remifentanil and ketamine (mean ± SD, 0.63 ± 0.4%), compared with concentration in cats given crystalloid fluids (1.22 ± 0.5%) but not compared with concentration in cats given remifentanil alone (1.03 ± 0.4%). Compared with cats given crystalloid fluids, mean isoflurane requirement was reduced by 48.3% in cats given remifentanil-ketamine and 15.6% in cats given remifentanil alone.CONCLUSIONS AND CLINICAL RELEVANCE: At the dosages administered, a constant rate infusion of remifentanil-ketamine resulted in a significant decrease in the isoflurane requirement in healthy cats undergoing ovariohysterectomy. However, significant differences in cardiovascular variables were not observed among treatment groups.

AB - OBJECTIVE: To evaluate the effects of a constant rate infusion of remifentanil, alone or in combination with ketamine, in healthy cats anesthetized with isoflurane.DESIGN: Randomized, controlled, clinical trial.ANIMALS: 23 cats undergoing elective ovariohysterectomy.PROCEDURES: Cats were premedicated with acepromazine and morphine; anesthesia was induced with propofol and maintained with isoflurane. Cats were given constant rate infusions of remifentanil (20 μg/kg/h [9 μg/lb/h], IV; n = 8), remifentanil and ketamine (0.5 mg/kg [0.23 mg/lb], then 1.8 mg/kg/h [0.82 mg/lb/h], IV; 7), or crystalloid fluids (8). The anesthesiologist was blinded to treatment group, end-tidal isoflurane concentration, and vaporizer setting. Heart rate, systolic arterial blood pressure, respiratory rate, end-tidal partial pressure of CO2, temperature, and end-tidal isoflurane concentration were monitored; recovery scores were assigned.RESULTS: There were no significant differences among treatment groups with respect to age, body weight, surgery time, anesthesia time, time to extubation, recovery score, or cardiorespiratory variables. End-tidal isoflurane concentration was significantly reduced in cats given remifentanil and ketamine (mean ± SD, 0.63 ± 0.4%), compared with concentration in cats given crystalloid fluids (1.22 ± 0.5%) but not compared with concentration in cats given remifentanil alone (1.03 ± 0.4%). Compared with cats given crystalloid fluids, mean isoflurane requirement was reduced by 48.3% in cats given remifentanil-ketamine and 15.6% in cats given remifentanil alone.CONCLUSIONS AND CLINICAL RELEVANCE: At the dosages administered, a constant rate infusion of remifentanil-ketamine resulted in a significant decrease in the isoflurane requirement in healthy cats undergoing ovariohysterectomy. However, significant differences in cardiovascular variables were not observed among treatment groups.

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DO - 10.2460/javma.246.9.976

M3 - Article

C2 - 25875668

SN - 0003-1488

VL - 246

SP - 976

EP - 981

JO - Journal of the American Veterinary Medical Association

JF - Journal of the American Veterinary Medical Association

IS - 9

ER -

Clinical effects of a constant rate infusion of remifentanil, alone or in combination with ketamine, in cats anesthetized with isoflurane

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Clinical effects of a constant rate infusion of remifentanil, alone or in combination with ketamine, in cats anesthetized with isoflurane

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