Clinical effects of isoflurane and sevoflurane in lambs

Enzo Vettorato, Gudrun Schoeffmann, John G Burke, Alastair J N Gibson, Eddie R Clutton

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Objective  To compare isoflurane and sevoflurane in lambs undergoing prolonged anaesthesia for spinal surgery. Study design  Prospective randomised clinical study. Animals  Eighteen Scottish blackface lambs 3-6 weeks of age and weighing 10-17 kg. Methods  After intramuscular medetomidine, anaesthesia was induced and maintained with either isoflurane (group I) or sevoflurane (group S) delivered in oxygen. Meloxicam, morphine, a constant rate infusion of ketamine and atracurium were given intravenously (IV) during surgery. Lungs were ventilated to maintain normocapnia. with peak inspiratory pressures of 20-25 cmH(2) O. Ephedrine or dextran 40% was administered when mean arterial pressure (MAP) was 1 minute), reunion with the ewe, and the number of MAP treatments were recorded. Statistical analysis utilised anova, Mann-Whitney, t-test or Pearson's correlation test as relevant. p 
Original languageEnglish
Pages (from-to)495-502
Number of pages8
JournalVeterinary Anaesthesia and Analgesia
Volume39
Issue number5
DOIs
Publication statusPublished - 2012

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