Clinical enzymology of the dog and cat

I L Oikonomidis, E Milne

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

Clinical enzymology studies the enzyme activity in serum or other body fluids for the diagnosis, prognosis or monitoring of a variety of diseases. Clinical enzymology has greatly benefited from advances in technology and is now an integral part of laboratory analysis. However, to maximise the clinical benefits of serum enzyme measurement, clinicians and clinical pathologists must have a good understanding of the pathophysiology behind serum enzyme alterations. They must also be aware of the preanalytical and analytical factors that can affect the accuracy of serum enzyme activity measurement. This review article first covers the basic concepts of clinical enzymology and the general mechanisms related to serum enzyme alterations. Then, the review discusses the potential effects of various preanalytical and analytical factors on enzyme activity measurement. Lastly, it explores the pathophysiology and clinical use of various serum enzymes in canine and feline medicine. The present review article aims to be a comprehensive one-stop source for clinical pathologists and small animal practitioners.

Original languageEnglish
Pages (from-to)465-478
Number of pages14
JournalAustralian veterinary journal
Issue number12
Early online date28 Sept 2023
Publication statusPublished - Dec 2023

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Cat Diseases/diagnosis
  • Cats
  • Dog Diseases/diagnosis
  • Dogs


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