Clinical Manifestations of an Outbreak of Monkeypox Virus in Captive Chimpanzees in Cameroon, 2016

Stephanie C Brien, Matthew LeBreton, Jeffrey B Doty, Matthew R Mauldin, Clint N Morgan, Emily G Pieracci, Jana M Ritter, Audrey Matheny, Bibila G Tafon, Ubald Tamoufe, Alain D Missoup, Julius Nwobegahay, Jean Michel Takuo, Felix Nkom, Moctar M M Mouiche, Jean Marc K Feussom, Kimberly Wilkins, Abel Wade, Andrea M McCollum

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Monkeypox virus (MPXV) is a re-emerging virus of global concern. An outbreak of Clade I MPXV affected 20 captive chimpanzees in Cameroon in 2016. We describe the epidemiology, virology, phylogenetics, and clinical progression of this outbreak. Clinical signs included exanthema, facial swelling, peri-laryngeal swelling, and eschar. Mpox can be lethal in captive chimpanzees with death likely resulting from respiratory complications. We advise avoiding anesthesia in animals with respiratory signs to reduce the likelihood of death. This outbreak presented a risk to animal care staff. There is a need for increased awareness and a One Health approach to preparation for outbreaks in wildlife rescue centers in primate range states where MPXV occurs. Control measures should include quarantining affected animals, limiting human contacts, surveillance of humans and animals, use of personal protective equipment, and regular decontamination of enclosures.

Original languageEnglish
Pages (from-to)S275-S284
JournalThe Journal of Infectious Diseases
Volume229
Issue numberSupplement_2
Early online date2 Jan 2024
DOIs
Publication statusPublished - 26 Mar 2024

Keywords / Materials (for Non-textual outputs)

  • One Health
  • epidemiology
  • mpox
  • outbreak
  • zoonosis

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