Clinical perspectives of emerging pathogens in bleeding disorders

Christopher A Ludlam, William G Powderly, Samuel Bozzette, Michael Diamond, Marion A Koerper, Roshni Kulkarni, Bruce Ritchie, Jamie Siegel, Peter Simmonds, Samuel Stanley, Michael L Tapper, Mario von Depka

Research output: Contribution to journalArticlepeer-review

Abstract

As a result of immunological and nucleic-acid screening of plasma donations for transfusion-transmissible viruses, and the incorporation of viral reduction processes during plasma fractionation, coagulation-factor concentrates (CFC) are now judged safe in terms of many known infectious agents, including hepatitis B and C viruses, HIV, and human T-cell lymphotropic virus. However, emerging pathogens could pose future threats, particularly those with blood-borne stages that are resistant to viral-inactivation steps in the manufacturing process, such as non-lipid-coated viruses. As outlined in this Review, better understanding of infectious diseases allows challenges from newly described agents of potential concern in the future to be anticipated, but the processes of zoonotic transmission and genetic selection or modification ensure that plasma-derived products will continue to be subject to infectious concerns. Manufacturers of plasma-derived CFC have addressed the issue of emerging infectious agents by developing recombinant products that limit the need for human plasma during production. Such recombinant products have extended the safety profile of their predecessors by ensuring that all reagents used for cell culture, purification steps, and stabilisation and storage buffers are completely independent of human plasma.
Original languageEnglish
Pages (from-to)252-61
Number of pages10
JournalThe Lancet
Volume367
Issue number9506
DOIs
Publication statusPublished - 21 Jan 2006

Keywords

  • Animals
  • Blood Coagulation Factors
  • Communicable Diseases, Emerging
  • Hemophilia A
  • Humans
  • Public Health
  • Viruses

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