Clinical Utility of an Epigenetic Assay to Detect Occult Prostate Cancer in Histopathologically Negative Biopsies: Results of the MATLOC Study

Grant D Stewart; Leander Van Neste; Philippe Delvenne; Paul Delrée; Agnès Delga; S Alan McNeill; Marie O'Donnell; James Clark; Wim Van Criekinge; Joseph Bigley; David J Harrison

doi:10.1016/j.juro.2012.08.219

Clinical Utility of an Epigenetic Assay to Detect Occult Prostate Cancer in Histopathologically Negative Biopsies: Results of the MATLOC Study

Grant D Stewart, Leander Van Neste, Philippe Delvenne, Paul Delrée, Agnès Delga, S Alan McNeill, Marie O'Donnell, James Clark, Wim Van Criekinge, Joseph Bigley, David J Harrison

Research output: Contribution to journal › Article › peer-review

Abstract

Concern about possible false-negative prostate biopsy histopathology findings often leads to rebiopsy. A quantitative methylation specific polymerase chain reaction assay panel, including GSTP1, APC and RASSF1, could increase the sensitivity of detecting cancer over that of pathological review alone, leading to a high negative predictive value and a decrease in unnecessary repeat biopsies.

Original language	English
Pages (from-to)	1110-1116
Number of pages	7
Journal	The Journal of urology
Volume	189
Issue number	3
DOIs	https://doi.org/10.1016/j.juro.2012.08.219
Publication status	Published - 2013

Keywords / Materials (for Non-textual outputs)

prostate
prostatic neoplasms
biopsy
epigenomics

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10.1016/j.juro.2012.08.219

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Stewart, G. D., Van Neste, L., Delvenne, P., Delrée, P., Delga, A., McNeill, S. A., O'Donnell, M., Clark, J., Van Criekinge, W., Bigley, J., & Harrison, D. J. (2013). Clinical Utility of an Epigenetic Assay to Detect Occult Prostate Cancer in Histopathologically Negative Biopsies: Results of the MATLOC Study. The Journal of urology, 189(3), 1110-1116. https://doi.org/10.1016/j.juro.2012.08.219

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abstract = "Concern about possible false-negative prostate biopsy histopathology findings often leads to rebiopsy. A quantitative methylation specific polymerase chain reaction assay panel, including GSTP1, APC and RASSF1, could increase the sensitivity of detecting cancer over that of pathological review alone, leading to a high negative predictive value and a decrease in unnecessary repeat biopsies.",

keywords = "prostate, prostatic neoplasms, biopsy, epigenomics",

author = "Stewart, {Grant D} and {Van Neste}, Leander and Philippe Delvenne and Paul Delr{\'e}e and Agn{\`e}s Delga and McNeill, {S Alan} and Marie O'Donnell and James Clark and {Van Criekinge}, Wim and Joseph Bigley and Harrison, {David J}",

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doi = "10.1016/j.juro.2012.08.219",

language = "English",

volume = "189",

pages = "1110--1116",

journal = "The Journal of urology",

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Stewart, GD, Van Neste, L, Delvenne, P, Delrée, P, Delga, A, McNeill, SA, O'Donnell, M, Clark, J, Van Criekinge, W, Bigley, J & Harrison, DJ 2013, 'Clinical Utility of an Epigenetic Assay to Detect Occult Prostate Cancer in Histopathologically Negative Biopsies: Results of the MATLOC Study', The Journal of urology, vol. 189, no. 3, pp. 1110-1116. https://doi.org/10.1016/j.juro.2012.08.219

TY - JOUR

T1 - Clinical Utility of an Epigenetic Assay to Detect Occult Prostate Cancer in Histopathologically Negative Biopsies

T2 - Results of the MATLOC Study

AU - Stewart, Grant D

AU - Van Neste, Leander

AU - Delvenne, Philippe

AU - Delrée, Paul

AU - Delga, Agnès

AU - McNeill, S Alan

AU - O'Donnell, Marie

AU - Clark, James

AU - Van Criekinge, Wim

AU - Bigley, Joseph

AU - Harrison, David J

PY - 2013

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AB - Concern about possible false-negative prostate biopsy histopathology findings often leads to rebiopsy. A quantitative methylation specific polymerase chain reaction assay panel, including GSTP1, APC and RASSF1, could increase the sensitivity of detecting cancer over that of pathological review alone, leading to a high negative predictive value and a decrease in unnecessary repeat biopsies.

KW - prostate

KW - prostatic neoplasms

KW - biopsy

KW - epigenomics

U2 - 10.1016/j.juro.2012.08.219

DO - 10.1016/j.juro.2012.08.219

M3 - Article

C2 - 22999998

SN - 1527-3792

VL - 189

SP - 1110

EP - 1116

JO - The Journal of urology

JF - The Journal of urology

IS - 3

ER -

Clinical Utility of an Epigenetic Assay to Detect Occult Prostate Cancer in Histopathologically Negative Biopsies: Results of the MATLOC Study

Abstract

Keywords / Materials (for Non-textual outputs)

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