Clinicopathological Findings, Treatment and Outcome in 60 cats with Feline Gastrointestinal Eosinophilic Sclerosing Fibroplasia

Petra Černá*, Cristobal Lopez-Jimenez, Kenjiro Fukushima, Ko Nakashima, Taisuke Nakagawa, Fiona Adams, Anna Groth, Andrew Denning, Nicolas Israeliantz Gunz, Danielle Gunn-Moore

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

BACKGROUND: Gastrointestinal eosinophilic sclerosing fibroplasia (GESF) in cats presents as mass(es) associated with the gastrointestinal tract, mesentery, and abdominal lymph nodes.

HYPOTHESIS/OBJECTIVES: To report the clinicopathological findings, treatment, and outcome of cats with GESF.

ANIMALS: Sixty client-owned cats diagnosed with GESF.

METHODS: Retrospective review of medical records of cats with histopathologically confirmed GESF.

RESULTS: The median age was 5.4 years (interquartile range [IQR], 3.3-8.9.); 30% were Domestic Shorthairs and 12% were Domestic Longhair cats, with the most prevalent pedigree breeds being Ragdolls (25%), Exotic Shorthair (10%) and Persian (8%) cats. The median duration of clinical signs was 90 days (IQR, 17.5-247.0); the most common clinical signs were weight loss (60%), hyporexia/anorexia (55%), chronic vomiting (37%), lethargy (35%) and chronic diarrhea (27%). Masses were located in the small intestine (32%), stomach (27%), ileocolic junction (15%), colon (10%), lymph node (8%) and mesentery (8%) and 15% of cats had >1 mass. Eosinophilia was present in 50% and hypoalbuminemia in 28% of cats. The mass was removed surgically in 37% of cases. Most cats (98%) were treated with corticosteroids. Survival was not statistically different between cats treated with surgical resection and cats treated with medical therapy alone, 88% of the cats were still alive at the time of writing.

CONCLUSIONS AND CLINICAL IMPORTANCE: GESF is an important differential diagnosis for abdominal masses in cats, and has a much better prognosis than previously reported.

Original languageEnglish
Pages (from-to)1005-1012
Number of pages8
JournalJournal of Veterinary Internal Medicine
Issue number2
Early online date11 Jan 2024
Publication statusPublished - 1 Mar 2024

Keywords / Materials (for Non-textual outputs)

  • eosinophilia
  • gastrointestinal mass
  • mesenteric mass
  • Ragdoll


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