Cloning and developmental expression analysis of ltd-1, the Caenorhabditis elegans homologue of the mouse kyphoscoliosis (ky) gene

J D Vargas; E Culetto; C P Ponting; I Miguel-Aliaga; K E Davies; D B Sattelle

Cloning and developmental expression analysis of ltd-1, the Caenorhabditis elegans homologue of the mouse kyphoscoliosis (ky) gene

J D Vargas, E Culetto, C P Ponting, I Miguel-Aliaga, K E Davies, D B Sattelle

Deanery of Molecular, Genetic and Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

We have characterized the developmental expression pattern of the Caenorhabditis elegans homologue of the mouse ky gene. The Ky protein has a putative key function in muscle development and has homologues in invertebrates, fungi and a cyanobacterium. The C. elegans Ky homologue gene has been named ltd-1 for LIM and transglutaminase domains gene. The LTD-1::GFP construct is expressed in developing hypodermal cells from the twofold stage embryo through adulthood. These data define the ltd-1 gene as a novel marker for C. elegans epithelial cell development.

Original language	English
Pages (from-to)	289-92
Number of pages	4
Journal	Mechanisms of Development
Volume	117
Issue number	1-2
Publication status	Published - Sep 2002

Keywords

Amino Acid Sequence
Animals
Animals, Genetically Modified
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cloning, Molecular
Gene Expression Regulation, Developmental
Genes, Helminth
Green Fluorescent Proteins
Luminescent Proteins
Mice
Molecular Sequence Data
Recombinant Fusion Proteins
Sequence Homology, Amino Acid

Cite this

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title = "Cloning and developmental expression analysis of ltd-1, the Caenorhabditis elegans homologue of the mouse kyphoscoliosis (ky) gene",

abstract = "We have characterized the developmental expression pattern of the Caenorhabditis elegans homologue of the mouse ky gene. The Ky protein has a putative key function in muscle development and has homologues in invertebrates, fungi and a cyanobacterium. The C. elegans Ky homologue gene has been named ltd-1 for LIM and transglutaminase domains gene. The LTD-1::GFP construct is expressed in developing hypodermal cells from the twofold stage embryo through adulthood. These data define the ltd-1 gene as a novel marker for C. elegans epithelial cell development.",

keywords = "Amino Acid Sequence, Animals, Animals, Genetically Modified, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Cloning, Molecular, Gene Expression Regulation, Developmental, Genes, Helminth, Green Fluorescent Proteins, Luminescent Proteins, Mice, Molecular Sequence Data, Recombinant Fusion Proteins, Sequence Homology, Amino Acid",

author = "Vargas, {J D} and E Culetto and Ponting, {C P} and I Miguel-Aliaga and Davies, {K E} and Sattelle, {D B}",

year = "2002",

month = sep,

language = "English",

volume = "117",

pages = "289--92",

journal = "Mechanisms of Development",

issn = "0925-4773",

publisher = "Elsevier Ireland Ltd",

number = "1-2",

}

TY - JOUR

T1 - Cloning and developmental expression analysis of ltd-1, the Caenorhabditis elegans homologue of the mouse kyphoscoliosis (ky) gene

AU - Vargas, J D

AU - Culetto, E

AU - Ponting, C P

AU - Miguel-Aliaga, I

AU - Davies, K E

AU - Sattelle, D B

PY - 2002/9

Y1 - 2002/9

N2 - We have characterized the developmental expression pattern of the Caenorhabditis elegans homologue of the mouse ky gene. The Ky protein has a putative key function in muscle development and has homologues in invertebrates, fungi and a cyanobacterium. The C. elegans Ky homologue gene has been named ltd-1 for LIM and transglutaminase domains gene. The LTD-1::GFP construct is expressed in developing hypodermal cells from the twofold stage embryo through adulthood. These data define the ltd-1 gene as a novel marker for C. elegans epithelial cell development.

AB - We have characterized the developmental expression pattern of the Caenorhabditis elegans homologue of the mouse ky gene. The Ky protein has a putative key function in muscle development and has homologues in invertebrates, fungi and a cyanobacterium. The C. elegans Ky homologue gene has been named ltd-1 for LIM and transglutaminase domains gene. The LTD-1::GFP construct is expressed in developing hypodermal cells from the twofold stage embryo through adulthood. These data define the ltd-1 gene as a novel marker for C. elegans epithelial cell development.

KW - Amino Acid Sequence

KW - Animals

KW - Animals, Genetically Modified

KW - Caenorhabditis elegans

KW - Caenorhabditis elegans Proteins

KW - Cloning, Molecular

KW - Gene Expression Regulation, Developmental

KW - Genes, Helminth

KW - Green Fluorescent Proteins

KW - Luminescent Proteins

KW - Mice

KW - Molecular Sequence Data

KW - Recombinant Fusion Proteins

KW - Sequence Homology, Amino Acid

M3 - Article

C2 - 12204272

VL - 117

SP - 289

EP - 292

JO - Mechanisms of Development

JF - Mechanisms of Development

SN - 0925-4773

IS - 1-2

ER -

Cloning and developmental expression analysis of ltd-1, the Caenorhabditis elegans homologue of the mouse kyphoscoliosis (ky) gene

Abstract

Keywords

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