Cloning and developmental expression analysis of ltd-1, the Caenorhabditis elegans homologue of the mouse kyphoscoliosis (ky) gene

J D Vargas, E Culetto, C P Ponting, I Miguel-Aliaga, K E Davies, D B Sattelle

Research output: Contribution to journalArticlepeer-review

Abstract

We have characterized the developmental expression pattern of the Caenorhabditis elegans homologue of the mouse ky gene. The Ky protein has a putative key function in muscle development and has homologues in invertebrates, fungi and a cyanobacterium. The C. elegans Ky homologue gene has been named ltd-1 for LIM and transglutaminase domains gene. The LTD-1::GFP construct is expressed in developing hypodermal cells from the twofold stage embryo through adulthood. These data define the ltd-1 gene as a novel marker for C. elegans epithelial cell development.

Original languageEnglish
Pages (from-to)289-92
Number of pages4
JournalMechanisms of Development
Volume117
Issue number1-2
Publication statusPublished - Sep 2002

Keywords

  • Amino Acid Sequence
  • Animals
  • Animals, Genetically Modified
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Cloning, Molecular
  • Gene Expression Regulation, Developmental
  • Genes, Helminth
  • Green Fluorescent Proteins
  • Luminescent Proteins
  • Mice
  • Molecular Sequence Data
  • Recombinant Fusion Proteins
  • Sequence Homology, Amino Acid

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