Abstract / Description of output
The sequence of a cDNA encoding the corticotropin-releasing factor precursor has been identified by screening lambda gt11 libraries constructed from poly(A)+ RNA of the hypothalamic region of the white sucker Catostomus commersoni brain with synthetic oligonucleotide probes deduced from the sequence of the rat corticotropin-releasing factor. The amino acid sequence of corticotropin-releasing factor of the sucker is strikingly conserved when compared to its counterpart from rat and differs only in two positions at the carboxyl terminus; in contrast, there is little similarity between their cryptic regions.
Original language | English |
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Pages (from-to) | 8439-43 |
Number of pages | 5 |
Journal | Proceedings of the National Academy of Sciences (PNAS) |
Volume | 85 |
Issue number | 22 |
Publication status | Published - Nov 1988 |
Keywords / Materials (for Non-textual outputs)
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- Codon
- DNA
- Fishes
- Genes
- Molecular Sequence Data
- Restriction Mapping