Clostridium difficile infections in South East Scotland: mortality and recurrence in a region without PCR ribotype 027

Surabhi K Taori, Allison Wroe, Ian R Poxton

Research output: Contribution to journalArticlepeer-review

Abstract

Three hundred and thirty-five patients with laboratory-confirmed Clostridium difficile infections (CDIs) were studied for epidemiological features, clinical presentation and laboratory markers. They were followed up for 1 year to determine recurrence and mortality. Four hundred and thirty-two episodes were recorded. One year mortality was 41.8 % of which CDI was listed on 20 % of the death certificates. One year recurrence rate was 22.9 %. PCR ribotype 001 was the commonest epidemiological type and ribotype 027 was not detected. High total leucocyte count and low albumin were significantly associated with mortality, as was the absence of a GI-invasive procedure in the 12 weeks preceding CDI diagnosis, probably due to patients being unfit for the procedure. No association with acid suppressants, deletion in the tdcC anti-sigma factor or vancomycin-resistant enterococcus/methicillin-resistant Staphylococcus aureus co-infection was detected. One year mortality was higher in patients who developed recurrent infections (P60 days, respectively, suggesting that the arbitrary cut-off of 28 days to call a repeat infection a reinfection may not be correct in some cases.
Original languageEnglish
Pages (from-to)1468-77
Number of pages10
JournalJournal of Medical Microbiology
Volume62
Issue numberPt 9
DOIs
Publication statusPublished - Sep 2013

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Child, Preschool
  • Clostridium Infections
  • Clostridium difficile
  • Coinfection
  • Comorbidity
  • Feces
  • Female
  • Gene Deletion
  • Genes, Bacterial
  • Humans
  • Leukocyte Count
  • Male
  • Methicillin-Resistant Staphylococcus aureus
  • Middle Aged
  • Polymerase Chain Reaction
  • Prospective Studies
  • Recurrence
  • Ribotyping
  • Scotland
  • Serum Albumin
  • Staphylococcal Infections
  • Young Adult

Fingerprint Dive into the research topics of 'Clostridium difficile infections in South East Scotland: mortality and recurrence in a region without PCR ribotype 027'. Together they form a unique fingerprint.

Cite this