Cluster-span threshold: An unbiased threshold for binarising weighted complete networks in functional connectivity analysis

Keith Smith, Hamed Azami, Mario A Parra, John M. Starr, Javier Escudero

Research output: Contribution to conferencePaperpeer-review

Abstract

We propose a new unbiased threshold for network analysis named the Cluster-Span Threshold (CST). This is based on the clustering coefficient, C, following logic that a balance of ‘clustering’ to ‘spanning’ triples results in a useful topology for network analysis and that the product of complementing properties has a unique value only when perfectly balanced. We threshold networks by fixing C at this balanced value, rather than fixing connection density at an arbitrary value, as has been the trend. We compare results from an electroencephalogram data set of volunteers performing visual short term memory tasks of the CST alongside other thresholds, including maximum spanning trees. We find that the CST holds as a sensitive threshold for distinguishing differences in the functional connectivity between tasks. This provides a sensitive and objective method for setting a threshold on weighted complete networks which may prove influential on the future of functional connectivity research.
Original languageEnglish
Pages2840-2843
Number of pages4
Publication statusPublished - 27 Aug 2015
Event37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - MiCo, Milan, Italy
Duration: 26 Aug 201529 Aug 2015

Conference

Conference37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Country/TerritoryItaly
CityMilan
Period26/08/1529/08/15

Keywords

  • connectivity measurements
  • nonlinear coupling of biomedical signals

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