CMV and natural killer cells: shaping the response to vaccination

Martin R. Goodier, Stipan Jonjić, Eleanor M. Riley, Vanda Juranić Lisnić*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Cytomegaloviruses (CMVs) are highly prevalent, persistent human pathogens that not only evade but also shape our immune responses. Natural killer (NK) cells play an important role in the control of CMV and CMVs have in turn developed a plethora of immunoevasion mechanisms targeting NK cells. This complex interplay can leave a long-lasting imprint on the immune system in general and affect responses toward other pathogens and vaccines. This review aims to provide an overview of NK cell biology and development, the manipulation of NK cells by CMVs and the potential impact of these evasion strategies on responses to vaccination.

Original languageEnglish
Pages (from-to)50-65
Number of pages16
JournalEuropean Journal of Immunology
Volume48
Issue number1
Early online date8 Nov 2017
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • CMV
  • HCMV
  • Immune evasion
  • NK cells
  • Vaccination

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