Co-circulation of enteroviruses between apes and humans

Heli Harvala, Dung Van Nguyen, Chloe McIntyre, Steve Ahuka-Mundeke, Eitel Mpoudi Ngole, Eric Delaporte, Martine Peeters, Peter Simmonds

Research output: Contribution to journalArticlepeer-review

Abstract

A total of 139 stool samples from wild chimpanzees, gorillas and bonobos in Cameroon and Democratic Republic of Congo (DRC) were screened for enteroviruses (EVs) by RT-PCR. EV RNA was detected in 10% of samples, comprising 8 from 58 sampled chimpanzees (13.8%), 1/40 bonobos (2.5%) and 5/40 gorillas (12.2%). Three chimpanzee variants grouped with human isolate EV-A89 while four (4 chimpanzee, 1 gorilla) represented a newly identified type, EV-A119. These species A virus types overlapped with those circulating in human populations in the same area. The remaining six strains comprised a new species D type, EV-D120, infecting one chimpanzee and 4 gorillas, and a single EV variant infecting a bonobo that was remarkably divergent from other EVs and potentially constitutes a new enterovirus species. The study demonstrates both the circulation of genetically divergent EV variants in apes and monkeys as well as those shared with local human populations.
Original languageEnglish
JournalJournal of General Virology
VolumeE-pub 4 November
Early online date4 Nov 2013
DOIs
Publication statusPublished - 4 Nov 2013

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